FlyBase Allele Report: Dmel\mei-P22[P22]

General Information

Symbol

Dmel\mei-P22^P22

Species

D. melanogaster

Name

FlyBase ID

FBal0088816

Feature type

allele

Associated gene

Dmel\mei-P22

Associated Insertion(s)

P{lacW}mei-P22^P22

Carried in Construct

Also Known As

mei-P22¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

P-element activity

(McKim et al., 1998)

Delta2-3 transposase

(Sekelsky et al., 1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}mei-P22^P22

Cytology

Description

P{lacW} element insertion 52bp upstream of the ATG.

(Liu et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:7,244,335..7,244,335 [+]

(Wei et al., 2019, Iida and Lilly, 2004, Liu et al., 2002, Sekelsky et al., 1999, McKim, 1998.3.10, McKim et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Liu et al., 2002, Sekelsky et al., 1999, McKim et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous females show 38.5% non-disjunction of the X chromosome. Crossing over on the second chromosome (al-cn interval) is reduced to 4.2% of wild type.

(Liu et al., 2002)

Mutant for female meiotic segregation: 29.9% X chromosome exceptions from X/X females. 22.8% 4th chromosome exceptions from X/X females. 35.4% X chromosome exceptions from X/Bal females. 22.4% 4th chromosome exceptions from X/Bal females. Recombination defective mutant. Females show no recombination.

(Sekelsky et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

mei-P22^P22 is a suppressor of ovariole phenotype of Gcna^KO

(Bhargava et al., 2020)

mei-P22^P22 is a suppressor of egg chamber phenotype of mio²

(Iida and Lilly, 2004)

mei-P22[+]/mei-P22^P22 is a suppressor of nurse cell phenotype of mio²

(Iida and Lilly, 2004)

mei-P22^P22/mei-P22^P22 is a suppressor of nurse cell phenotype of mio²

(Iida and Lilly, 2004)

mei-P22[+]/mei-P22^P22 is a suppressor of oocyte phenotype of mio²

(Iida and Lilly, 2004)

mei-P22^P22/mei-P22^P22 is a suppressor of oocyte phenotype of mio²

(Iida and Lilly, 2004)

mei-P22^P22 is a suppressor of phenotype of mei-41^D18

(McKim et al., 2000)

NOT Suppressor of

Statement

Reference

mei-P22^P22/mei-P22^P22 is a non-suppressor of egg chorion phenotype of blv³/blv¹

(Barbosa et al., 2007)

mei-P22[+]/mei-P22^P22 is a non-suppressor of egg chorion phenotype of blv³/blv¹

(Barbosa et al., 2007)

mei-P22^P22/mei-P22^P22 is a non-suppressor of egg chorion phenotype of nds⁴/nds²

(Barbosa et al., 2007)

mei-P22[+]/mei-P22^P22 is a non-suppressor of egg chorion phenotype of nds⁴/nds²

(Barbosa et al., 2007)

mei-P22^P22/mei-P22^P22 is a non-suppressor of egg chorion phenotype of trin³/trin¹

(Barbosa et al., 2007)

mei-P22[+]/mei-P22^P22 is a non-suppressor of egg chorion phenotype of trin³/trin¹

(Barbosa et al., 2007)

mei-P22^P22/mei-P22^P22 is a non-suppressor of egg chorion phenotype of SRPK⁴/SRPK²

(Barbosa et al., 2007)

mei-P22[+]/mei-P22^P22 is a non-suppressor of egg chorion phenotype of SRPK⁴/SRPK²

(Barbosa et al., 2007)

mei-P22^P22/mei-P22^P22 is a non-suppressor of egg chorion phenotype of bha²/bha¹

(Barbosa et al., 2007)

mei-P22[+]/mei-P22^P22 is a non-suppressor of egg chorion phenotype of bha²/bha¹

(Barbosa et al., 2007)

Other

Statement

Reference

mei-41^D18, mei-P22^P22 has oocyte nucleus & meiotic cell cycle phenotype

(McKim et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Transformation of oocytes to nurse cells in mio² homozygous females is partially suppressed by mei-P22^P22/+ or mei-P22^P22/mei-P22^P22. The block in oogenesis at around stage 5 seen in mio² homozygous females is also partially suppressed by mei-P22^P22, producing egg chambers that often undergo vitellogenesis and develop to the late stages of oogenesis.

(Iida and Lilly, 2004)

In mei-41^D18; mei-P22^P22 oocyte nuclei premature anaphases are seen.

(McKim et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4931

y¹ w¹/Dp(1;Y)y⁺; P{lacW}mei-P22^P22; sv^spa-pol

Notes on Origin

Discoverer

Comments

No gene conversion or intragenic crossovers are observed in an assay of intragenic recombination at ry. The frequency of cross over on the entire X and second chromosome is much reduced: isolated recombination events suggest that the recombination taken place is in fact a mitotic and not a meiotic event. Examination of oocytes to study meiotic recombination events in sister chromatids reveals there are no cross over events. Double stranded breaks are not left unrepaired. Synaptonemal complex formation is not disrupted, meiotic progression is normal.

(McKim et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

mei-P22

(Sekelsky et al., 1999)

mei-P22¹

(Bhargava et al., 2020, Barbosa et al., 2007, Liu et al., 2002, McKim et al., 2000)

mei-P22^McKim

mei-P22^P22

(Wei et al., 2019)

Name Synonyms

Secondary FlyBase IDs

FBal0086410

References (9)

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