FB2024_03 , released June 25, 2024
Allele: Dmel\nSybI18
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General Information
Symbol
Dmel\nSybI18
Species
D. melanogaster
Name
FlyBase ID
FBal0088777
Feature type
allele
Associated gene
Dmel\nSyb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Deitcher et al., 1998)
Mutagen
ethyl methanesulfonate
(Deitcher et al., 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A reduction is seen in EJCs in n-sybΔF33B/n-sybI18 larvae over a full range of Ca2+ concentrations. Sensitivity to Calcium is not altered. There are no differences in mEJC amplitude that can explain the observed reduction in synaptic transmission. A reduction in Ca2+ cooperativity of synaptic transmission is seen. The mean mEJC decay time is not affected.

      (Stewart et al., 2000)

      Transheterozygotes with n-sybF33 or n-sybΔF33B can survive to adulthood, but the flies are very sluggish and often remain motionless for minutes at a time. n-sybI18/n-sybF33 adults are very uncoordinated.

      (Deitcher et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      n-SybI18
      n-sybI18
      n-sybhypo
      (Stewart et al., 2000)
      nSybI18
      Name Synonyms
      Secondary FlyBase IDs
        References (3)