FlyBase Allele Report: Dmel\Kr-h1[10642]

General Information

Symbol

Dmel\Kr-h1¹⁰⁶⁴²

Species

D. melanogaster

Name

FlyBase ID

FBal0087045

Feature type

allele

Associated gene

Dmel\Kr-h1

Associated Insertion(s)

P{PZ}Kr-h1¹⁰⁶⁴²

Carried in Construct

Also Known As

l(2)10642

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Kr-h1¹⁰⁶⁴²

Cytology

Description

P{PZ} insertion in the 5' UTR.

(Benevolenskaya et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:6,083,215..6,083,215 [+]

(McClure and Schubiger, 2008, McGovern et al., 2003, Abrell et al., 2000, Benevolenskaya et al., 2000, Liebl, 1999, Spradling et al., 1999, Benevolenskaya, 1998.3.10, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

The central nervous system of Kr-h1¹⁰⁶⁴² embryos appears normal.

(McGovern et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Kr-h1¹⁰⁶⁴² is an enhancer of visible | dominant phenotype of Kr^If-1

(Abrell et al., 2000)

Kr-h1¹⁰⁶⁴² is an enhancer of abnormal eye color phenotype of w^a

(Benevolenskaya et al., 2000)

Suppressor of

Statement

Reference

Kr-h1¹⁰⁶⁴²/Kr-h1[+] is a suppressor of visible | somatic clone phenotype of wg^Act5C.PS

(McClure and Schubiger, 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Kr-h1¹⁰⁶⁴² is an enhancer of eye phenotype of Kr^If-1

(Abrell et al., 2000)

Kr-h1¹⁰⁶⁴² is an enhancer of ommatidium phenotype of Kr^If-1

(Abrell et al., 2000)

Kr-h1¹⁰⁶⁴² is an enhancer of pigment cell phenotype of w^a

(Benevolenskaya et al., 2000)

Suppressor of

Statement

Reference

Kr-h1¹⁰⁶⁴²/Kr-h1[+] is a suppressor of leg | somatic clone phenotype of wg^Act5C.PS

(McClure and Schubiger, 2008)

Kr-h1¹⁰⁶⁴²/Kr-h1[+] is a suppressor of wing | ectopic | somatic clone phenotype of wg^Act5C.PS

(McClure and Schubiger, 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of leg-to-wing transdetermination caused by expression of wg^Act5C.PS in clones during the mid-second larval instar is dominantly suppressed by Kr-h1¹⁰⁶⁴².

(McClure and Schubiger, 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Kr-h1^k16802

(BDGP Project Members, 1994-1999)

Kr-h1^k05905

(BDGP Project Members, 1994-1999)

Kr-h1^k04411

(BDGP Project Members, 1994-1999)