FB2024_03 , released June 25, 2024
Allele: Dmel\Sec1301031
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General Information
Symbol
Dmel\Sec1301031
Species
D. melanogaster
Name
FlyBase ID
FBal0086959
Feature type
allele
Associated gene
Dmel\Sec13
Associated Insertion(s)
P{PZ}Sec1301031
Carried in Construct
Also Known As
l(3)01031
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{PZ}Sec1301031
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The accumulation of en-positive granules in the salivary glands is not altered detectably in sec1301031 mutants. sec1301031 mutants have major defects in cuticular development; the larval cuticles are smaller (on average only 40-50% the length of wild-type) and weaker than the cuticles of their wild-type siblings, the mouthparts and filzkorper are poorly formed, and sec1301031 mutants frequently have large holes in the dorsal cuticle. In addition, there appears to be a general defect in patterning of the cuticle, with dorsal and ventral structures appearing more lateralized. The ventral cuticle exhibits a loss of denticles and the denticles that are present have a very light pigmentation, more consistent with the pigmentation found in more lateral denticles of wild-type larvae. The dorsal surfaces of the mutant larvae consist of thin hairs and naked cuticle, an arrangement more typical of dorsal-lateral reiogns of wild-type cuticles.

      (Abrams and Andrew, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Sec1301031/Sec13[+] is an enhancer of visible | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)

      Sec1301031/Sec13[+] is an enhancer of decreased size | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)
      NOT Suppressor of
      Statement
      Reference

      Sec1301031/sec13[+] is a non-suppressor of lethal | recessive | third instar larval stage phenotype of PolE1pl10R

      (Verma et al., 2012)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Sec1301031/Sec13[+] is an enhancer of wing phenotype of dpyD

      (Kandasamy et al., 2021)
      Other
      Statement
      Reference

      Sec1301031, Yif1doc-1/Yif1[+] has wing phenotype

      (Kandasamy et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sec1301031, Yif1doc-1 double heterozygotes show a small, oblique wing phenotype.

      (Kandasamy et al., 2021)

      sec1301031 complements the lethality seen in DNApol-εpl10R.

      (Verma et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Reversion analysis proved that the P{PZ} is responsible for the lethal phenotype.

      (Beaton, 2000.1.31)

      Complements: pnt07825.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Sec1301031
      (Kim et al., 2015)
      l(3)01031
      (Abrams and Andrew, 2005, Spradling et al., 1999)
      l(3)0103101031
      (BDGP Project Members, 1994-1999)
      sec1301031
      (Kandasamy et al., 2021, Salzer et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)