FB2024_03 , released June 25, 2024
Allele: Dmel\slmb2
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General Information
Symbol
Dmel\slmb2
Species
D. melanogaster
Name
FlyBase ID
FBal0083749
Feature type
allele
Associated gene
Dmel\slmb
Associated Insertion(s)
Carried in Construct
Also Known As
slimb2
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Muzzopappa and Wappner, 2005)
Mutagen
ethyl methanesulfonate
(Jiang and Struhl, 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: A443T.

(Skwarek et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,121,080..21,121,080 [-]
Nucleotide change:

G21121080A

Amino acid change:

A443T | slmb-PA; A443T | slmb-PB; A443T | slmb-PC

Reported amino acid change:

A443T

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Skwarek et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A limited amount of neoplastic transformation is seen in slmb2 mutant wing disc clones.

      (Skwarek et al., 2014)

      slmb2 mutant neuroblast clones result in mushroom body γ neurons retain many larval axons at 24 hours after puparium formation that are pruned in wild type. In wandering third instar larvae the dorsal and medial axons are projected normally but the axon branches are less dense than in wild type.

      (Wong et al., 2013)

      9.9% of egg chambers with slmb2 germline clones show extra germ cells.

      (Muzzopappa and Wappner, 2005)

      Homozygotes and slmb1/slmb2 transheterozygotes carrying a single copy of slmbαTub84B.PJ are viable and show normal morphology, 5-10% of adults exhibit duplication of the haltere. Mutant cells undergo only a few divisions and show phenotypes characteristic of ectopic wg and hh signal transduction. slmb1/slmb2 transheterozygotes are pupal lethal. Heterozygotes with Df(3R)e-R1 or slmb00295 die during early larval life.

      (Jiang and Struhl, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      lin19BG02329/+; slmb2 and CSN5L4032/+; slmb2 germline clones show enhanced phenotypes compared to slmb2 germline clones: the proportion of egg chambers with extra germ cells is increased and germaria are enlarged.

      (Muzzopappa and Wappner, 2005)

      smo3; slmb1/slmb2 clones generate a supernumerary 'double-anterior' wing.

      (Jiang and Struhl, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (10)