FB2024_03 , released June 25, 2024
Allele: Dmel\kuzH143
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General Information
Symbol
Dmel\kuzH143
Species
D. melanogaster
Name
FlyBase ID
FBal0082860
Feature type
allele
Associated gene
Dmel\kuz
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        kuzH143 mutants exhibit thinning of the longitudinal connectives and thickening of the commissures compared to controls. 50% of the segments examined in kuzH143 homozygous mutants display FasII axon crossing defects. No FasII axon crossing defects are seen in kuzH143/+. However kuzH143 heterozygotes do exhibit mild ectopic ap neuron crossing.

        (Coleman et al., 2010)

        Homozygous clones induced in the thorax at 48-72 hours after egg laying are missing macrochaetae and microchaetae, and a tuft of macrochaetae develops in the area devoid of bristles. Homozygous clones induced in the dorsal part of the wing at 48-72 hours after egg laying give rise to thickening of the wing veins and nicks at the wing margin.

        (Sotillos et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        kuzH143 has abnormal neuroanatomy | embryonic stage 16 | dominant phenotype, enhanceable by sli2/sli[+]

        (Coleman et al., 2010)

        kuzH143 has abnormal neuroanatomy | embryonic stage 16 phenotype, enhanceable by robo[+]/sli[+]/robo15/sli1

        (Coleman et al., 2010)
        Enhancer of
        Statement
        Reference

        kuzH143 is an enhancer of abnormal neuroanatomy | embryonic stage 16 | dominant phenotype of robo15, sli[+]/sli1

        (Coleman et al., 2010)

        kuz[+]/kuzH143 is an enhancer of abnormal neuroanatomy | embryonic stage 16 | dominant phenotype of sli2

        (Coleman et al., 2010)
        NOT Enhancer of
        NOT Suppressor of
        Statement
        Reference

        kuzH143 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4eg-Mz360, fraΔC.UAS.Tag:HA

        (Zang et al., 2022)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        kuzH143 has commissure | embryonic stage 16 phenotype, enhanceable by sli2/sli[+]

        (Coleman et al., 2010)

        kuzH143 has larval longitudinal connective | embryonic stage 16 phenotype, enhanceable by robo[+]/sli[+]/robo15/sli1

        (Coleman et al., 2010)

        kuzH143 has commissure | embryonic stage 16 phenotype, enhanceable by robo[+]/sli[+]/robo15/sli1

        (Coleman et al., 2010)

        kuzH143 has larval longitudinal connective | embryonic stage 16 phenotype, enhanceable by sli2/sli[+]

        (Coleman et al., 2010)
        Enhancer of
        Statement
        Reference

        kuzH143 is an enhancer of larval longitudinal connective | embryonic stage 16 phenotype of robo15, sli[+]/sli1

        (Coleman et al., 2010)

        kuzH143 is an enhancer of commissure | embryonic stage 16 phenotype of robo15, sli[+]/sli1

        (Coleman et al., 2010)

        kuz[+]/kuzH143 is an enhancer of larval longitudinal connective | embryonic stage 16 phenotype of sli2

        (Coleman et al., 2010)

        kuz[+]/kuzH143 is an enhancer of commissure | embryonic stage 16 phenotype of sli2

        (Coleman et al., 2010)
        NOT Enhancer of
        NOT Suppressor of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        One copy each of sli1 and robo5 enhances the FasII axon midline crossing phenotype seen in kuzH143 stage 16 embryos.

        A kuzH143 background enhances the FasII midline crossing phenotype seen in sli1, robo5 transheterozygous stage 16 embryos.

        kuzH143, sli2 transheterozygous stage 16 embryos display a stronger ectopic ap neuron crossing phenotype than either mutant alone.

        (Coleman et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        kuzH143
        (Zang et al., 2022, Coleman et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)