FB2024_03 , released June 25, 2024
Allele: Dmel\lz114
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General Information
Symbol
Dmel\lz114
Species
D. melanogaster
Name
FlyBase ID
FBal0082466
Feature type
allele
Associated gene
Dmel\lz
Associated Insertion(s)
Carried in Construct
Also Known As
lzts114
Key Links
Genomic Maps

Allele class

heat sensitive loss of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive loss of function allele

(Gupta et al., 1998, Gupta and Rodrigues, 1995)
Mutagen
ethyl methanesulfonate
(Gupta and Rodrigues, 1995)
Progenitor genotype
lzts1
(Gupta and Rodrigues, 1995)
Cytology
Description

Amino acid replacement: N351I.

(Jackson Behan et al., 2005)

Amino acid replacement: Y681term.

(Jackson Behan et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:9,288,521..9,288,521 [+]
Nucleotide change:

A9288521T

Reported nucleotide change:

A11268T

Amino acid change:

N351I | lz-PA; N351I | lz-PB

Reported amino acid change:

N351I

Comment:

One of two amino acid substitutions in mutant.

(Jackson Behan et al., 2005, Gupta and Rodrigues, 1995)
point_mutation
X:9,302,433..9,302,433 [+]
Nucleotide change:

T9302433A

Reported nucleotide change:

T25180A

Amino acid change:

Y681term | lz-PA; Y560term | lz-PB

Reported amino acid change:

Y681

Comment:

One of two amino acid substitutions in mutant.

(Jackson Behan et al., 2005, Gupta and Rodrigues, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sensilla basiconic are completely absent in lz114 flies, concomitant with an increase in trichoid sensilla. This increase is believed to be due to conversion of sense organ identities resulting in the presence of trichoid sensilla in domains on the antennal surface normally occupied by sensilla basiconica.

      (Bhalerao et al., 2003)

      Hemizygous males have disrupted facets in the eye at 25oC.

      (Li and Gergen, 1999)

      lz114 behaves as a hypomorph at 25[o]C, but is amorphic at 28[o]C.

      (Gupta et al., 1998)

      Flies have strong defects in the eye, antenna and maxillary palps. There is a decrease in the number of basiconic sensilla and an increase in the number of trichoid sensilla on the antenna compared to wild-type flies. This phenotype is much stronger at 25oC than 18oC.

      (Gupta and Rodrigues, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      lz114 has visible | recessive phenotype, enhanceable by Bro::Hsap\MYH11UAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)

      lz114 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)2051

      (Gupta and Rodrigues, 1995)

      lz114 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)151

      (Gupta and Rodrigues, 1995)

      lz114 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)531

      (Gupta and Rodrigues, 1995)

      lz114 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)1741

      (Gupta and Rodrigues, 1995)

      lz114 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)1781

      (Gupta and Rodrigues, 1995)
      Suppressed by
      Statement
      Reference

      lz114 has visible | recessive phenotype, suppressible by BroUAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)

      lz114 has visible | recessive phenotype, suppressible by BgbUAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      lz114 has eye phenotype, enhanceable by Bro::Hsap\MYH11UAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)

      lz114 has ommatidium phenotype, enhanceable by Bro::Hsap\MYH11UAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)

      lz114 has eye phenotype, enhanceable by E(lz)1781

      (Gupta and Rodrigues, 1995)

      lz114 has eye phenotype, enhanceable by E(lz)2051

      (Gupta and Rodrigues, 1995)

      lz114 has eye phenotype, enhanceable by E(lz)151

      (Gupta and Rodrigues, 1995)

      lz114 has eye phenotype, enhanceable by E(lz)531

      (Gupta and Rodrigues, 1995)

      lz114 has eye phenotype, enhanceable by E(lz)1741

      (Gupta and Rodrigues, 1995)
      Suppressed by
      Statement
      Reference

      lz114 has eye phenotype, suppressible by BroUAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)

      lz114 has ommatidium phenotype, suppressible by BroUAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)

      lz114 has eye phenotype, suppressible by BgbUAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)

      lz114 has ommatidium phenotype, suppressible by BgbUAS.cLa/Scer\GAL4hs.2sev

      (Li and Gergen, 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The eye phenotype but not the antennal or maxillary palp sensilla phenotype of lz114 flies is dominantly enhanced by E(lz)151, E(lz)531, E(lz)1741, E(lz)1781 and E(lz)2051.

      (Gupta and Rodrigues, 1995)
      Xenogenetic Interactions
      Statement
      Reference

      The hemizygous eye phenotype is enhanced by expression of Bro::Hsap\MYH11Scer\UAS.cLa under the control of Scer\GAL4hs.2sev, is completely rescued by expression of BroScer\UAS.cLa under the control of Scer\GAL4hs.2sev and is almost completely rescued by expression of BgbScer\UAS.cLa under the control of Scer\GAL4hs.2sev.

      (Li and Gergen, 1999)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      lz114
      lzts114
      (Nagaraj and Banerjee, 2007, Jackson Behan et al., 2005, Li and Gergen, 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)