FlyBase Allele Report: Dmel\Ras85D[bE382]

General Information

Symbol

Dmel\Ras85D^bE382

Species

D. melanogaster

Name

FlyBase ID

FBal0065996

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Fischer et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: E63K.

(Li et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:9,511,949..9,511,949 [-]

Nucleotide change:

G9511949A

Amino acid change:

E63K | Ras85D-PA

Reported amino acid change:

E63K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Li et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Fischer et al., 1997)

lethal - all die during embryonic stage | recessive

(Li et al., 1997)

some die during embryonic stage | recessive

(Li et al., 1997)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygotes are viable.

(Li et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Ras85D^bE382 is an enhancer of phenotype of faf^BX3

(Fischer et al., 1997)

Other

Statement

Reference

Ras85D^bE382, faf^BX3 has eye photoreceptor cell phenotype

(Li et al., 1997)

Ras85D^bE382, faf^FO8 has eye photoreceptor cell phenotype

(Li et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the faf^BX3 eye phenotype: facets are often missing the R7 receptor cell.

(Fischer et al., 1997)

Heterozygous phenotype is enhanced by loss of faf activity.

(Li et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutation is not a simple hypermorph or hypomorph. The protein does provide some wild type activity and also antagonises the wild-type function in some manner.

(Li et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

E(faf)bE382

(Li et al., 1997)

Ras1^E63K

(Li et al., 1997)

Ras85D^bE382

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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