FlyBase Allele Report: Dmel\faf[BX3]

General Information

Symbol

Dmel\faf^BX3

Species

D. melanogaster

Name

FlyBase ID

FBal0031251

Feature type

allele

Associated gene

Dmel\faf

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Fischer-Vize et al., 1992)

Mutagen

X ray

(Fischer-Vize et al., 1992)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Fischer-Vize et al., 1992)

Description

15bp deletion.

(Chen and Fischer, 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates epilepsy

modeled by pk^sple-1

(Paemka et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Fischer-Vize et al., 1992)

partially lethal - majority die (with Df(3R)faf-BP)

(Stinchfield et al., 2012)

visible | recessive

(Fischer-Vize et al., 1992)

Phenotype Manifest In

cone cell (with faf^FO8)

(Chen et al., 2000)

embryo | embryonic stage 4 | maternal effect (with faf^FO8)

(Chen et al., 2000)

embryonic/first instar larval cuticle | non-rescuable maternal effect (with faf^B4)

(Stinchfield et al., 2012)

embryonic head | non-rescuable maternal effect (with faf^B4)

(Stinchfield et al., 2012)

eye photoreceptor cell

(Li et al., 1997)

eye photoreceptor cell | increased number (with faf^FO8)

(Chen et al., 2000)

filzkorper | non-rescuable maternal effect (with faf^B4)

(Stinchfield et al., 2012)

ommatidium (with faf^FO8)

(Chen et al., 2000)

ventral denticle belt | ectopic | non-rescuable maternal effect (with faf^B4)

(Stinchfield et al., 2012)

Detailed Description

Statement

Reference

Embryos derived from faf^B4/faf^BX3 females mated to wild-type males show significant ventralisation of the cuticle, with a herniated head, defective Filzkorper, malformed dorsal cuticle and extended denticle belts.

(Stinchfield et al., 2012)

faf^BX3/faf^FO8 eyes are nearly wild type.

(Cadavid et al., 2000)

faf^BX3/faf^FO8 flies have facets with more than the wild-type number of photoreceptor cell and an abnormal number of cone cells.

(Chen et al., 2000)

faf^FO8/faf^BX3 flies have essentially wild-type eyes.

(Wu et al., 1999)

faf^BX3/faf^FO8 and homozygous adults exhibit nearly wild type eyes with a smooth exterior.

(Fischer et al., 1997)

Most facets of homozygotes and transheterozygotes with faf^FO8 contain more than the normal complement of 8 photoreceptor cells, many facets have extra R7 cells and a small proportion have missing R7 cells.

(Li et al., 1997)

Mutation causes no significant alteration to the variegated eye phenotype of In(1)w^m4h.

(Henchoz et al., 1996)

Eyes roughened due to abnormalities in the hexagonal facet array: but only 1% of facets are affected. Ovaries of homozygous females are normal in appearance but the embryos produced never form syncytial blastoderm and all fail to hatch.

(Fischer-Vize et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

faf^FO8/faf^BX3 has visible phenotype, enhanceable by shi[+]/shi^EM45

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has visible phenotype, enhanceable by shi¹/shi¹

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has visible phenotype, enhanceable by shi²/shi²

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has visible | recessive phenotype, enhanceable by Chc[+]/Chc¹

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has visible phenotype, enhanceable by Chc[+]/Chc¹

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has visible phenotype, enhanceable by lqf^AG/lqf[+]

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has visible | recessive phenotype, enhanceable by Chc[+]/Chc⁴

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has visible phenotype, enhanceable by Chc[+]/Chc⁴

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has visible phenotype, enhanceable by Chc[+]/Chc¹

(Cadavid et al., 2000)

faf^BX3 has visible phenotype, enhanceable by Chc⁴

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has visible phenotype, enhanceable by shi^EM42/shi[+]

(Cadavid et al., 2000)

Suppressed by

Statement

Reference

faf^FO8/faf^BX3, lqf^bE25 has visible phenotype, suppressible by eff^XS347

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has visible phenotype, suppressible by eff⁰¹⁴⁶²

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has visible | recessive phenotype, suppressible by Prosβ6^rv10e

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has visible | recessive phenotype, suppressible by Prosβ6¹

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has visible phenotype, suppressible by Prosβ6^rv10e

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has visible phenotype, suppressible by Prosβ6¹

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has visible | recessive phenotype, suppressible by eff^XS347

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has visible | recessive phenotype, suppressible by eff⁰¹⁴⁶²

(Cadavid et al., 2000)

Suppressor of

Statement

Reference

faf^BX3/faf[+] is a suppressor of bang sensitive | dominant phenotype of pk^sple-1

(Paemka et al., 2015)

Other

Statement

Reference

faf^BX3, lqf^bE25 has visible | recessive phenotype

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has visible phenotype

(Cadavid et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

faf^FO8/faf^BX3 has eye phenotype, enhanceable by shi[+]/shi^EM45

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has eye phenotype, enhanceable by shi¹/shi¹

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has eye phenotype, enhanceable by shi²/shi²

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has wing phenotype, enhanceable by Chc[+]/Chc¹

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has eye phenotype, enhanceable by Chc[+]/Chc¹

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has wing phenotype, enhanceable by Chc[+]/Chc⁴

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has eye phenotype, enhanceable by Chc[+]/Chc⁴

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has eye phenotype, enhanceable by lqf^AG/lqf[+]

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has eye phenotype, enhanceable by Chc[+]/Chc¹

(Cadavid et al., 2000)

faf^FO8/faf^BX3 has eye phenotype, enhanceable by shi^EM42/shi[+]

(Cadavid et al., 2000)

faf^BX3 has phenotype, enhanceable by Ras85D^bE382

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by E(faf)bE160^bE160

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by E(faf)bE184^bE184

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by E(faf)bE184^bE198

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by E(faf)bE184^bE377

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by E(faf)bE184^bE432

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by lqf^bE248

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by E(faf)bE365^bE365

(Fischer et al., 1997)

faf^BX3 has phenotype, enhanceable by lqf^bE25

(Fischer et al., 1997)

NOT Enhanced by

Statement

Reference

faf^FO8/faf^BX3 has ommatidium phenotype, non-enhanceable by arm¹/arm[+]

(Chen et al., 2000)

faf^FO8/faf^BX3 has ommatidium phenotype, non-enhanceable by arm⁴/arm[+]

(Chen et al., 2000)

faf^FO8/faf^BX3 has ommatidium phenotype, non-enhanceable by cno³/cno[+]

(Chen et al., 2000)

faf^FO8/faf^BX3 has ommatidium phenotype, non-enhanceable by cno²/cno[+]

(Chen et al., 2000)

Suppressed by

Statement

Reference

faf^FO8/faf^BX3, lqf^bE25 has ommatidium phenotype, suppressible by eff^XS347

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has ommatidium phenotype, suppressible by eff⁰¹⁴⁶²

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has ommatidium phenotype, suppressible by Prosβ6^rv10e

(Cadavid et al., 2000)

faf^FO8/faf^BX3, lqf^bE25 has ommatidium phenotype, suppressible by Prosβ6¹

(Cadavid et al., 2000)

Enhancer of

Statement

Reference

faf^BX3 is an enhancer of eye photoreceptor cell phenotype of Rap1^E8

(Li et al., 1997)

faf^BX3 is an enhancer of eye photoreceptor cell phenotype of Rap1^E127

(Li et al., 1997)

Other

Statement

Reference

faf^BX3, lqf^bE25 has wing phenotype

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has ommatidium phenotype

(Cadavid et al., 2000)

faf^BX3, lqf^bE25 has eye photoreceptor cell | ectopic phenotype

(Cadavid et al., 2000)

eff^ro.Tag:MYC, faf^FO8/faf^BX3 has eye phenotype

(Wu et al., 1999)

Ras85D^bE382, faf^BX3 has eye photoreceptor cell phenotype

(Li et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of faf^BX3/+ rescues the bang-sensitive phenotype of pk^sple-1/+ mutants.

(Paemka et al., 2015)

The eyes of faf^BX3/faf^FO8 flies are severely malformed if the flies are also carrying one copy of lqf^AG. Nearly all facets of lqf^bE25 faf^BX3/faf^BX3 eyes contain one or more ectopic photoreceptors in addition to the normal complement of 8. The faf^BX3/faf^FO8 phenotype is dominantly enhanced by Chc¹, no enhancement if seen with Chc⁴. The faf^BX3/faf^FO8 phenotype is dominantly enhanced by shi^EM42 or shi^EM45. The faf^BX3/faf^FO8 phenotype is slightly enhanced if the flies are also homozygous for shi¹ or shi². The lqf^bE25 faf^BX3/faf^BX3 mutant phenotype is dominantly enhanced by Chc¹ or Chc⁴. The lqf^bE25 faf^BX3/faf^FO8 mutant phenotype is suppressed by eff^XS347, eff⁰¹⁴⁶², Pros26^rv10e or Pros26¹.

(Cadavid et al., 2000)

The addition of three copies of P{ro-UbcD1.T:Hsap\MYC} to faf^FO8/faf^BX3 flies enhances the eye phenotype.

(Wu et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Weak allele.

(Fischer et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

faf^BX3

(Paemka et al., 2015, Stinchfield et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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