FlyBase Allele Report: Dmel\Prosβ6[rv10e]

General Information

Symbol

Dmel\Prosβ6^rv10e

Species

D. melanogaster

Name

FlyBase ID

FBal0095632

Feature type

allele

Associated gene

Dmel\Prosβ6

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

loss of function allele

(Neuburger et al., 2006, Smyth and Belote, 1999)

Mutagen

ethyl nitrosourea

(Neuburger et al., 2006)

Progenitor genotype

Prosβ6¹

(Neuburger et al., 2006)

Cytology

Description

Nonsense mutation truncating the open reading frame at amino acid 78.

(Smyth and Belote, 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,610,011..16,610,011 [-]

Nucleotide change:

G16610011A

Amino acid change:

W78term | Prosbeta6-PA

Reported amino acid change:

?78term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Smyth and Belote, 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Pros26¹/Pros26^rv10e animals show early larval lethality at 25^oC.

(Neuburger et al., 2006)

Homozygotes and hemizygotes usually survive past hatching, but are sluggish and die as first instar larvae.

(Smyth and Belote, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Prosβ6^rv10e is a suppressor of visible phenotype of faf^FO8/faf^BX3, lqf^bE25

(Cadavid et al., 2000)

Prosβ6^rv10e is a suppressor of visible | recessive phenotype of faf^FO8/faf^BX3, lqf^bE25

(Cadavid et al., 2000)

Phenotype Manifest In

Suppressor of

Statement

Reference

Prosβ6^rv10e is a suppressor of ommatidium phenotype of faf^FO8/faf^BX3, lqf^bE25

(Cadavid et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Pros26^rv10e shows no synthetic lethal interaction with Prosβ2¹.

(Neuburger et al., 2006)

The lqf^bE25 faf^BX3/faf^FO8 mutant phenotype is suppressed by Pros26^rv10e.

(Cadavid et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Pros26^rv10e

(Neuburger et al., 2006)

Prosβ6^rv10e

l(3)73Ai^1rv10e

(Cadavid et al., 2000)

l(3)73Ai^rv10e

(Smyth and Belote, 1999)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close