FlyBase Allele Report: Dmel\hid[unspecified]

General Information

Symbol

Dmel\hid^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0065920

Feature type

allele

Associated gene

Dmel\hid

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | dominant

(Rancourt et al., 1991)

increased cell death

(Udan et al., 2003)

viable

(Rancourt et al., 1991)

Phenotype Manifest In

embryo | dorsal closure stage

(Zhou et al., 1999)

embryonic brain

(Zhou et al., 1999)

midline glial cell

(Bergmann et al., 2002)

Detailed Description

Statement

Reference

W^unspecified mutant embryos at stage 17 have an average of 5.8 midline glial cells per segment (n=182), compared to an average of 2.8 per segment in wild-type.

(Bergmann et al., 2002)

Embryos often show defects in head involution and the brain appears larger than normal.

(Zhou et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hid^unspecified has increased cell death phenotype, suppressible by hpo^KC202

(Udan et al., 2003)

Suppressor of

Statement

Reference

W[+]/hid^unspecified is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, ttm50^UAS.Tag:HA

(Sugiyama et al., 2007)

hid^unspecified is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^unspecified, hpo^UAS.cUa

(Udan et al., 2003)

hid^unspecified is a suppressor of increased cell death | larval stage phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

hid^unspecified is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^cv-c-C5, hpo^UAS.cUa

(Udan et al., 2003)

Other

Statement

Reference

hid^unspecified, pie^EB3/pie[+] has lethal | dominant phenotype

(Shi et al., 2003)

W[+]/hid^unspecified, pie^EB3 has lethal | dominant phenotype

(Shi et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

hid^unspecified/hid^unspecified is an enhancer of midline glial cell phenotype of rl^Sem

(Bergmann et al., 2002)

Suppressor of

Statement

Reference

W[+]/hid^unspecified is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, ttm50^UAS.Tag:HA

(Sugiyama et al., 2007)

hid^unspecified/hid^unspecified is a suppressor of midline glial cell phenotype of rl^unspecified

(Bergmann et al., 2002)

hid^unspecified is a suppressor of midline glial cell phenotype of comm^Δe39

(Bergmann et al., 2002)

hid^unspecified is a suppressor of Malpighian tubule phenotype of Egfr^f24

(Sudarsan et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of ttm50^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed by W^unspecified/+.

(Sugiyama et al., 2007)

pie^EB3/+ is lethal in combination with W^unspecified/+.

(Shi et al., 2003)

hpo^KC202 mutant clones partially suppress the cell death observed in eye discs that ectopically express W^unspecified.

(Udan et al., 2003)

The reduction in midline glial cell numbers seen in comm^Δe39 mutant embryos is suppressed in double mutants with W^unspecified. These rescued midline glial cells are scattered throughout the midline, which lacks axons in these animals. The absence of midline glia (MG) in rl^unspecified embryos is suppressed by W^unspecified/W^unspecified, although the resulting cells are mislocated, lying directly below the cuticle, often in clusters of up to 20 cells. Approximately twice as many MG cells survive as in wild-type.

(Bergmann et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

W^unspecified

hid

(Sudarsan et al., 2002)

hid^unspecified

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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