FlyBase Allele Report: Dmel\Itpr[B4]

General Information

Symbol

Dmel\Itpr^B4

Species

D. melanogaster

Name

FlyBase ID

FBal0063164

Feature type

allele

Associated gene

Dmel\Itpr

Associated Insertion(s)

P{lacZ}Itpr^B4

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Venkatesh and Hasan, 1997)

Mutagen

P-element activity

(Venkatesh and Hasan, 1997)

Progenitor genotype

Associated Insertion(s)

P{lacZ}Itpr^B4

Cytology

Description

P{lacZ} insertion into the first intron.

(Venkatesh and Hasan, 1997)

Allele components

Component

Use(s)

Inserted element

P{lacZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:5,521,721..5,526,725

(Venkatesh and Hasan, 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage

(Raghu et al., 2000)

lethal - all die before end of larval stage | recessive

(Venkatesh and Hasan, 1997)

some die during larval stage

(Raghu et al., 2000)

some die during larval stage | recessive

(Venkatesh and Hasan, 1997)

Phenotype Manifest In

interommatidial bristle | somatic clone

(Raghu et al., 2000)

Detailed Description

Statement

Reference

Homozygous clones in the retina can result in defects in the mechanosensory bristles of the ommatidia, including duplication and missing and misplaced bristles.

(Raghu et al., 2000)

Homozygotes mostly die as late second instar larvae, between 88 and 184 hours after egg-laying. Homozygotes show a delay in moulting from first to second instar larvae compared to wild-type.

(Venkatesh and Hasan, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Itpr^B4/Itp-r83A[+] is an enhancer of abnormal size | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Itpr^B4/Itp-r83A[+] is an enhancer of increased cell number | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Itpr^B4/Itp-r83A[+] is an enhancer of increased cell number | adult stage phenotype of sl⁹

(Murillo-Maldonado et al., 2011)

NOT Enhancer of

Statement

Reference

Itpr^B4/Itp-r83A[+] is a non-enhancer of abnormal size | adult stage phenotype of sl⁹

(Murillo-Maldonado et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

Itpr^B4/Itp-r83A[+] is an enhancer of wing blade phenotype of sl²

(Murillo-Maldonado et al., 2011)

Itpr^B4/Itp-r83A[+] is an enhancer of wing vein | ectopic phenotype of sl²

(Murillo-Maldonado et al., 2011)

Itpr^B4/Itp-r83A[+] is an enhancer of photoreceptor cell R7 | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Itpr^B4/Itp-r83A[+] is an enhancer of photoreceptor cell R7 | adult stage phenotype of sl⁹

(Murillo-Maldonado et al., 2011)

NOT Enhancer of

Statement

Reference

Itpr^B4/Itp-r83A[+] is a non-enhancer of wing blade phenotype of sl⁹

(Murillo-Maldonado et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Itp-r83A^B4 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Itp-r83A^B4 does not enhance the reduction in wing blade area seen in homozygous sl⁹ males.

One copy of Itp-r83A^B4 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Itp-r83A^B4 enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

One copy of Itp-r83A^B4 enhances the percentage of sl⁹ mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

(Murillo-Maldonado et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Itpr^hc1

(Joshi et al., 2004)

Itpr^hc7

(Joshi et al., 2004)

Itpr^ka1091

(Joshi et al., 2004)