FlyBase Allele Report: Dmel\if[UAS.cMBa]

General Information

Symbol

Dmel\if^UAS.cMBa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Martin-Bermudo

FlyBase ID

FBal0062798

Feature type

allele

Associated gene

Dmel\if

Associated Insertion(s)

Carried in Construct

P{UAS-if.c/g}

Also Known As

UAS-PS2, UAS::αPS2

Key Links

Transgenic product class

wild_type

(Martin-Bermudo et al., 1997)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Martin-Bermudo et al., 1997)

Mutagen

in vitro construct

(Martin-Bermudo et al., 1998, Martin-Bermudo et al., 1997)

Progenitor genotype

Carried in construct

P{UAS-if.c/g}

Cytology

Description

UAS regulatory sequences drive expression of if. The if coding sequences are a fusion of genomic and cDNA sequences that should allow alternative splicing of exon 8.

(Martin-Bermudo et al., 1997)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^48Y/if^UAS.cMBa is a suppressor of lethal phenotype of mew^M6

(Martin-Bermudo et al., 1997)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Scer\GAL4^btl.PS/if^UAS.cMBa is a non-suppressor of embryonic/larval visceral tracheal branch phenotype of mew^M6

(Boube et al., 2001)

Scer\GAL4^48Y/if^UAS.cMBa is a non-suppressor of embryonic/larval midgut | embryonic stage phenotype of mew^M6

(Martin-Bermudo et al., 1999)

Other

Statement

Reference

Scer\GAL4^Mef2.PR, if^UAS.cMBa, mys^din.UAS has embryonic/larval somatic muscle cell phenotype

(Gilsohn and Volk, 2010)

Scer\GAL4^how-24B, if^UAS.cMBa, mys^din.UAS has muscle cell phenotype

(Tanentzapf et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of if^{Scer\UAS.cMBa} and mys^din.Scer\UAS in the somatic muscle under the control of Scer\GAL4^Mef2.PR leads to pointed morphology of the muscle ends and subsequent torn muscles.

(Gilsohn and Volk, 2010)

Expression of mys^din.Scer\UAS and if^{Scer\UAS.cMBa} under the control of Scer\GAL4^how-24B results in a muscle-detachment phenotype.

(Tanentzapf et al., 2006)

Does not rescue the migration defects of the midgut endodermal cells in mew^M6 embryos, when expressed under the control of Scer\GAL4^48Y.

(Martin-Bermudo et al., 1999)

Partially rescues the first instar lethality of mew^M6 homozygotes when expressed using Scer\GAL4^48Y, although the animals do not survive past the second larval instar stage.

(Martin-Bermudo et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^btl.PS/if^UAS.cMBa rescues if^B4

(Boube et al., 2001)

Scer\GAL4^twi.PG, Scer\GAL4^how-24B, if^UAS.cMBa rescues if^B4

(Martin-Bermudo et al., 1999)

Scer\GAL4^twi.PG, Scer\GAL4^how-24B, if^UAS.cMBa rescues if^B4

(Martin-Bermudo et al., 1998)