Expression of JraScer\UAS.cEa under the control of Scer\GAL4Hand.ΔVM.Switch (initiated by feeding flies RU486 during adulthood) results in cardiac function defects. Heart period (mean time between successive end-diastolic positions) is increased in 3 day and 10 day old flies compared to age-matched controls. No difference is seen in older flies.
Expression of JraScer\UAS.cEa in the RP2 motor neurons (using the Scer\GAL4eve.RRK driver to drive expression of Scer\FLP1Scer\UAS.cUa which then induces clones of cells expressing Scer\GAL4Act.PU) has no significant effect on RP2 dendrite volume.
Expression of JraScer\UAS.cEa under the control of either Scer\GAL4pnr-MD237, Scer\GAL4ey.PH or Scer\GAL4how-24B does not cause a phenotype.
Expression of JraScer\UAS.cEa under the control of Scer\GAL4elav-C155 does not affect EJC amplitude (synaptic strength) and bouton number at the larval neuromuscular junction. mEJC amplitude is not significantly altered.
Flies expressing JraScer\UAS.cEa under the control of Scer\GAL4tim.Scer\UAS have wild-type locomotor activity rhythms.
Causes no effect on copper cell development, when expression is driven by Scer\GAL448Y.
JraUAS.cEa, Scer\GAL4elav-C155 has abnormal neuroanatomy phenotype, enhanceable by kayUAS.cEa, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has abnormal neurophysiology phenotype, suppressible by sggEY02862, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has abnormal neurophysiology phenotype, suppressible | partially by dncUAS.cCa, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has abnormal neurophysiology phenotype, suppressible | partially by CrebBb.hs
JraUAS.cEa, Scer\GAL4GMR.PF is an enhancer of visible phenotype of Atf3UAS.cSa, Scer\GAL4GMR.PF
JraUAS.cEa, Scer\GAL4elav-C155 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4elav-C155, kayUAS.cEa
JraUAS.cEa, Scer\GAL4how-24B is a non-enhancer of lethal | pharate adult stage P14 phenotype of Mnn1UAS.cCa, Scer\GAL4how-24B
JraUAS.cEa, Scer\GAL4ey.PH is a suppressor of neoplasia phenotype of DeltaUAS.cDa, Scer\GAL4ey.PH, lolaGS88A8, psqGS88A8
JraUAS.cEa/kayUAS.cEa, Scer\GAL4elav-C155 is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4elav-C155, sggEY02862
JraUAS.cEa, Scer\GAL4hs.2sev is a suppressor | partially of abnormal planar polarity phenotype of Scer\GAL4hs.2sev, pntP2.UAS
JraUAS.cEa, Scer\GAL4how-24B is a non-suppressor of lethal | pharate adult stage P14 phenotype of Mnn1UAS.cCa, Scer\GAL4how-24B
JraUAS.cEa, Scer\GAL4futsch-C380, Scer\GAL80ChAT.3.3P, kayUAS.cEa has abnormal neuroanatomy phenotype
JraUAS.cEa, Scer\GAL4103.3, kayUAS.cEa has abnormal neuroanatomy phenotype
JraUAS.cEa, Scer\GAL4futsch-C380, kayUAS.cEa has abnormal neuroanatomy phenotype
JraUAS.cEa, Scer\GAL4Toll-6-D42, Scer\GAL80ChAT.3.3P, kayUAS.cEa has abnormal neuroanatomy phenotype
JraUAS.cEa, Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK, kayUAS.cEa has abnormal neuroanatomy | somatic clone phenotype
JraUAS.cEa, Scer\GAL4elav.PH, kayUAS.cEa has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has abnormal neuroanatomy phenotype
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has abnormal neurophysiology phenotype
JraUAS.cEa has synapse phenotype, enhanceable by Scer\GAL4elav-C155/kayUAS.cEa
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has synapse phenotype, suppressible by cnkEY06675, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has synapse phenotype, suppressible by Fkbp14EY02405, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has synapse phenotype, suppressible by Pde8EY10143, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has synapse phenotype, suppressible by sggEY02862, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has synapse phenotype, suppressible by SdcEY04602, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype, suppressible by kayUAS.cEa, Scer\GAL4ey.3.5.Exel
JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by cnkEY06675, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by Fkbp14EY02405, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by Pde8EY10143, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by sggEY02862, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, suppressible by SdcEY04602, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has neuromuscular junction | larval stage phenotype, suppressible | partially by dncUAS.cCa, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has neuromuscular junction | larval stage phenotype, suppressible | partially by CrebBb.hs
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has synapse phenotype, non-suppressible by Sema2aEY08184, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayFbz.UAS has synapse phenotype, non-suppressible by Sema2aEY08184, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has bouton | increased number phenotype, non-suppressible by CrebBb.hs
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has bouton | increased number phenotype, non-suppressible by dncUAS.cCa, Scer\GAL4elav-C155
JraUAS.cEa, Scer\GAL4GMR.PF is an enhancer of eye phenotype of Atf3UAS.cSa, Scer\GAL4GMR.PF
Scer\GAL4how-24B/JraUAS.cEa is a non-enhancer of adult thorax phenotype of Mnn1UAS.cCa, Scer\GAL4pnr-MD237
JraUAS.cEa, Scer\GAL4ey.PH is a suppressor of eye phenotype of DeltaUAS.cDa, Scer\GAL4ey.PH, lolaGS88A8, psqGS88A8
JraUAS.cEa/kayUAS.cEa, Scer\GAL4elav-C155 is a suppressor of synapse phenotype of Scer\GAL4elav-C155, sggEY02862
JraUAS.cEa, Scer\GAL4ey.3.5.Exel is a suppressor of eye phenotype of Scer\GAL4ey.3.5.Exel, kayFbz.UAS, kayUAS.cEa
JraUAS.cEa, Scer\GAL4hs.2sev is a suppressor | partially of ommatidium phenotype of Scer\GAL4hs.2sev, pntP2.UAS
Scer\GAL4how-24B/JraUAS.cEa is a non-suppressor of adult thorax phenotype of Mnn1UAS.cCa, Scer\GAL4pnr-MD237
Scer\GAL4MZ980/JraUAS.cEa is a non-suppressor of adult thorax | pharate adult stage phenotype of chm14
Scer\GAL4MZ980, JraUAS.cEa, kayUAS.cEa is a non-suppressor of adult thorax | pharate adult stage phenotype of chm14
JraUAS.cEa, Scer\GAL4Toll-6-D42, Scer\GAL80ChAT.3.3P, kayUAS.cEa has dendrite phenotype
JraUAS.cEa, Scer\GAL4103.3, kayUAS.cEa has indirect flight muscle motor neuron DLMN5 phenotype
JraUAS.cEa, Scer\GAL4103.3, kayUAS.cEa has dendrite phenotype
JraUAS.cEa, Scer\GAL4futsch-C380, Scer\GAL80ChAT.3.3P, kayUAS.cEa has dendrite phenotype
JraUAS.cEa, Scer\GAL4nAChRα7-3295, kayUAS.cEa has dendrite phenotype
JraUAS.cEa, Scer\GAL4futsch-C380, kayUAS.cEa has dendrite phenotype
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has synapse phenotype
JraUAS.cEa, Scer\GAL4ey.3.5.Exel, kayFbz.UAS has eye phenotype
JraUAS.cEa, Scer\GAL4futsch-C380, Scer\GAL80ChAT.3.3P, kayUAS.cEa has motor neuron phenotype
JraUAS.cEa, Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK, kayUAS.cEa has dendrite | somatic clone phenotype
JraUAS.cEa, Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK, kayUAS.cEa has larval RP2 motor neuron | somatic clone phenotype
JraUAS.cEa, Scer\GAL4elav.PH, kayUAS.cEa has NMJ bouton | somatic clone phenotype
JraUAS.cEa, Scer\GAL4elav.PH, kayUAS.cEa has embryonic/larval neuromuscular junction | somatic clone phenotype
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has neuromuscular junction | larval stage phenotype
JraUAS.cEa, Scer\GAL4elav-C155, kayUAS.cEa has bouton | increased number phenotype
Co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa under the control of Scer\GAL4D42 in the presence of Scer\GAL80Cha.PK (to suppress expression in cholinergic neurons) results in a significant increase in total dendritic length and in the number of dendritic branches in MN5 motorneurons. The length and radii of individual dendrite segments and dendritic territory borders are unaffected.
Co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa under the control of Scer\GAL4103.3 results in a significant increase in total dendritic length and in the number of dendritic branches in MN5 motorneurons. The length and radii of individual dendrite segments and dendritic territory borders are unaffected.
Co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa under the control of Scer\GAL4futsch-C380 in the presence of Scer\GAL80Cha.PK (to suppress expression in cholinergic neurons) results in a significant decrease in total dendritic length and in the number of dendritic branches in MN5 motorneurons. The length and radii of individual dendrite segments are unaffected. The dendrites do not reach the normal neuropil boundaries and appear less ramified with several parts missing. The most severe defects are in the proximal-posterior region.
Co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa under the control of Scer\GAL4gfA-3295 results in a significant reduction in the number of adult MN5 dendrites.
Co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa under the control of Scer\GAL4futsch-C380 results in significantly fewer dendritic branches in the MN5 motorneurons. If expression is delayed past pupal stage P6 by using the temperature-sensitive Scer\GAL80ts.αTub84B allele, then no obvious dendritic defects are seen.
The mutant eye phenotype caused by expression of Atf3Scer\UAS.cSa under the control of Scer\GAL4GMR.PF is exacerbated by co-expression of JraScer\UAS.cEa.
Co-expression of JraScer\UAS.cEa reduces tumor and metastasis incidence in the 'eyeful' (Scer\GAL4ey.PH, DlScer\UAS.cDa, psqGS88A8, lolaGS88A8) background.
Co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa pan-neurally under the control of Scer\GAL4elav-C155 positively regulates synaptic strength.
Co-expression of JraScer\UAS.cEa and kayScer\UAS.cEa in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 increases synaptic size (measured as the number of synaptic boutons) compared to wild-type controls.
Co-expression of JraScer\UAS.cEa and kayScer\UAS.cEa rescues the small eye phenotype seen upon expression of kayFbz.Scer\UAS in the eye disc using Scer\GAL4ey.3.5.Exel.
Co-expression of JraScer\UAS.cEa and kayScer\UAS.cEa in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 increases synaptic size (measured as the number of synaptic boutons) compared to wild-type controls.
Expression of sggEY02862 suppresses the reduced EJC amplitude found upon expression of kayScer\UAS.cEa and JraScer\UAS.cEa pan-neurally under the control of Scer\GAL4elav-C155.
Co-expression of cnkEY06675 in flies already expressing JraScer\UAS.cEa and kayScer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155, significantly reduces synaptic growth compared to JraScer\UAS.cEa and kayScer\UAS.cEa over-expression flies.
Co-expression of Fkbp13EY02405 in flies already expressing JraScer\UAS.cEa and kayScer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155, significantly reduces synaptic growth compared to JraScer\UAS.cEa and kayScer\UAS.cEa over-expression flies.
Co-expression of Pde8EY10143 in flies already expressing JraScer\UAS.cEa and kayScer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155, significantly reduces synaptic growth compared to JraScer\UAS.cEa and kayScer\UAS.cEa over-expression flies.
Co-expression of sggEY02862 in flies already expressing JraScer\UAS.cEa and kayScer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155, significantly reduces synaptic growth compared to JraScer\UAS.cEa and kayScer\UAS.cEa over-expression flies.
Co-expression of SdcEY04602 in flies already expressing JraScer\UAS.cEa and kayScer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155, significantly reduces synaptic growth compared to JraScer\UAS.cEa and kayScer\UAS.cEa over-expression flies.
Co-expression of Sema-2aEY08184 in flies already expressing JraScer\UAS.cEa and kayScer\UAS.cEa, all in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155, does not affect synaptic growth compared to JraScer\UAS.cEa and kayScer\UAS.cEa over-expression flies.
Co-expression of both kayScer\UAS.cEa and JraScer\UAS.cEa in the RP2 motor neurons (using the Scer\GAL4eve.RRK driver to drive expression of Scer\FLP1Scer\UAS.cUa which then induces clones of cells expressing Scer\GAL4Act.PU) results in a significant increase in RP2 dendrite volume compared to controls.
Cultured motor neurons co-expressing both kayScer\UAS.cEa and JraScer\UAS.cEa under the control of Scer\GAL4futsch-C380 (in the presence of Scer\GAL80Cha.PK to suppress expression in cholinergic neurons) show a significant increase in both neurite length and branch number compared to controls.
Simultaneous co-expression of JraScer\UAS.cEa and kayScer\UAS.cEa under the control of Scer\GAL4elav.PH in clones induced by FLP/FRT mediated recombination (to activate the Scer\GAL4elav.PH driver) results in an increase in the number of type 1b boutons at muscle 13 compared to wild type.
Co-expression of JraScer\UAS.cEa partially suppresses the symmetrical ommatidia phenotype caused by expression of pntP2.Scer\UAS under the control of Scer\GAL4hs.2sev.
Coexpression of Mnn1Scer\UAS.cCa and JraScer\UAS.cEa under the control of either Scer\GAL4pnr-MD237, Scer\GAL4ey.PH or Scer\GAL4how-24B results in the same phenotypes as expression of Mnn1Scer\UAS.cCa alone.
Expression of both kayScer\UAS.cEa and JraScer\UAS.cEa under the control of Scer\GAL4elav-C155 results in a 30% increase in EJC amplitude (synaptic strength) and bouton number at the larval neuromuscular junction. mEJC amplitude is not significantly altered. Expression of CrebB-17Ab.hs does not change the effect of co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa (under the control of Scer\GAL4elav-C155) on bouton number, but significantly inhibits the effect of co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa (under the control of Scer\GAL4elav-C155) on EJC amplitude (synaptic strength); the triple mutant flies have an EJC amplitude 108% that of control flies. Expression of dncScer\UAS.cCa under the control of Scer\GAL4elav-C155 does not change the effect of co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa (under the control of Scer\GAL4elav-C155) on bouton number, but significantly inhibits the effect of co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa (under the control of Scer\GAL4elav-C155) on EJC amplitude (synaptic strength); the triple mutant flies have an EJC amplitude 83% that of control flies. Expression of pucScer\UAS.cMa under the control of Scer\GAL4elav-C155 suppresses the effect of co-expression of kayScer\UAS.cEa and JraScer\UAS.cEa (under the control of Scer\GAL4elav-C155) on bouton number and EJC amplitude (synaptic strength) at the larval neuromuscular junction.