FB2024_03 , released June 25, 2024
Allele: Dmel\cher1
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General Information
Symbol
Dmel\cher1
Species
D. melanogaster
Name
FlyBase ID
FBal0060473
Feature type
allele
Associated gene
Dmel\cher
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Sokol et al., 1997)

    loss of function allele

    (Robinson et al., 1997)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  myopathy
        CEA with Act88F6
        (González-Morales et al., 2017)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In cher1 mutants, egg chamber ring canals lack the robust F-actin cytoskeleton found in wild type controls.

        (Hudson et al., 2019)

        cher1 heterozygotes do not exhibit a significant change in the number of recognizable sarcomeres in adult indirect flight muscles, as compared to controls. cher1/Df(3R)Exel6176 transheterozygotes exhibit widening of Z-discs at the adult indirect flight muscle sarcomeres, as compared to controls.

        (González-Morales et al., 2017)

        cher1 homozygous embryos display increased frequency of defasciculation defects in axons of the intersegmental nerve b, segmental nerve as well as intersegmental nerve (no obvious defects in the morphology and development of ventrolateral muscles are observed).

        (Jeong et al., 2017)

        Removing cher, through inducing cher1 mitotic clones within the developing eye-antennal imaginal disc, has no impact on clone number or morphology and results in adults with regular eyes.

        (Külshammer and Uhlirova, 2013)

        Homozygous embryos show defects in the guidance of the intersegmental nerve in the periphery.

        (Zheng et al., 2011)

        Homozygous larvae have lamellocytes in the circulation without any immune challenge (in contrast to wild-type controls). The number of these cells in the circulation is further increased following infestation with a parasitoid wasp.

        (Rus et al., 2006)

        chersko/cher1 females are sterile and have defects in ring canal assembly and egg chamber morphology.

        (Li et al., 1999)

        Egg chambers of homozygous females have impaired cytoplasm transport from nurse cell to oocyte. The egg chamber phenotype of cher1 homozygotes is less severe than that of cher1 homozygotes. Homozygous egg chambers lack the actin inner rim of the ring canals, although subcortical actin appears normal. The fusomes ares normal in the early germaria and develop into normal branched polyfusomes.

        (Robinson et al., 1997)

        Defective in cytoplasm transport.

        (Sokol et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        cher1, Act88F6 double heterozygotes frequently present myofibrils that are too frayed to distinguish individual sarcomeres, as compared to the corresponding single heterozygous controls.

        (González-Morales et al., 2017)

        Loss of cher markedly interferes with the growth of Ras85DV12.Scer\UAS scrib1 tumours. The loss of cher does not affect the level of apoptosis in either the clonal nor the surrounding eye-antennal imaginal disc, indicating that loss of cher does not affect tumour cell viability.

        Eye-antennal imaginal discs carrying Ras85DV12.Scer\UAS scrib1 cher1 clones display extra cell divisions, mainly occurring in the surrounding non-clonal tissue.

        (Külshammer and Uhlirova, 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        chersko

        (Li et al., 1999)
        Rescued by

        cher1 is rescued by cherhsp70.PS

        (Rus et al., 2006)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (14)