FB2024_03 , released June 25, 2024
Allele: Dmel\upd1sisC-5
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General Information
Symbol
Dmel\upd1sisC-5
Species
D. melanogaster
Name
FlyBase ID
FBal0059936
Feature type
allele
Associated gene
Dmel\upd1
Associated Insertion(s)
Carried in Construct
Also Known As
updsisC5
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    In(1)sisC5
    Cytology
    Description

    Inversion chromosome, with the proximal breakpoint just downstream of the first upd1 exon.

    (Sefton et al., 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Migration of prospective border follicle cells in upd1sisC-5/upd1YM55 animals is delayed or defective. Marker analysis suggests that these cells are at least partially transformed to a nurse follicle cell fate.

        (Xi et al., 2003)

        In upd1sisC-5 egg chambers, border cell migration is dramatically inhibited. The outer border cell clusters also consist of an average of 2.5 cells, as compared to 6 in wild-type.

        (Silver and Montell, 2001)

        Viability is variably reduced (females more than males), females are sterile and flies show tergite defects.

        (Sefton et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 1 )
        Crossreferences
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        UpdsisC5
        (Silver and Montell, 2001)
        ossisC-5
        sisC5
        (Sefton et al., 2000)
        upd1sisC-5
        updsisC5
        (Xi et al., 2003)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)