FB2024_03 , released June 25, 2024
Allele: Dmel\Eb15
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General Information
Symbol
Dmel\Eb15
Species
D. melanogaster
Name
FlyBase ID
FBal0057106
Feature type
allele
Associated gene
Dmel\Eb1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Roote, 1996.12.3)
Progenitor genotype
Cytology
Description

Amino acid replacement: C252Y.

(Elliott et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:6,755,047..6,755,047 [+]
Nucleotide change:

G6755047A

Amino acid change:

C252Y | Eb1-PA; C252Y | Eb1-PB; C252Y | Eb1-PD; C251Y | Eb1-PE; C258Y | Eb1-PF; C252Y | Eb1-PG

Reported amino acid change:

C252Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Elliott et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      All Eb15/Eb104524 viable escapers hold their wings in an abnormal 'downward' position and are flightless. Eb12/Eb15 flies also show this phenotype but at a lower frequency, with some of flies of this genotype showing held-up or parted wings. All Eb12/Eb15 flies are flightless, whether or not they hold their wings in a normal position.

      (Elliott et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Eb15/Eb1[+] is a suppressor of decreased occurrence of cell division phenotype of CycEJP

      (Brumby et al., 2004)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Eb15/Eb1[+] is a suppressor of eye disc & S phase phenotype of CycEJP

      (Brumby et al., 2004)

      Eb15/Eb1[+] is a suppressor of eye phenotype of CycEJP

      (Brumby et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly suppresses the S phase defects seen in the CycEJP eye disc.

      (Brumby et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      1DL
      (Brumby et al., 2004, Roote, 1996.12.3)
      DmEB15
      (Elliott et al., 2005)
      Eb15
      (Hahn et al., 2021)
      dEB15
      (Brumby et al., 2004)
      l(2)045245
      Name Synonyms
      Secondary FlyBase IDs
        References (4)