FlyBase Allele Report: Dmel\Eb1[2]

General Information

Symbol

Dmel\Eb1²

Species

D. melanogaster

Name

FlyBase ID

FBal0057109

Feature type

allele

Associated gene

Dmel\Eb1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Roote, 1996.12.3)

Progenitor genotype

Cytology

Description

Amino acid replacement: I93N.

(Elliott et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:6,754,190..6,754,190 [+]

Nucleotide change:

T6754190A

Amino acid change:

Reported amino acid change:

I93N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Elliott et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior (with Eb1⁰⁴⁵²⁴)

(Elliott et al., 2005)

abnormal wound healing | embryonic stage

(Abreu-Blanco et al., 2012)

female fertile (with Eb1⁰⁴⁵²⁴)

(Baskar et al., 2019)

flightless (with Eb1⁵)

(Elliott et al., 2005)

flightless (with Eb1⁰⁴⁵²⁴)

(Elliott et al., 2005)

partially lethal (with Eb1⁰⁴⁵²⁴)

(Baskar et al., 2019)

partially lethal - majority die (with Eb1⁰⁴⁵²⁴)

(Elliott et al., 2005)

visible (with Eb1⁵)

(Elliott et al., 2005)

visible (with Eb1⁰⁴⁵²⁴)

(Elliott et al., 2005)

Phenotype Manifest In

wing (with Eb1⁵)

(Elliott et al., 2005)

wing (with Eb1⁰⁴⁵²⁴)

(Elliott et al., 2005)

Detailed Description

Statement

Reference

Eb1⁰⁴⁵²⁴/Eb1² escaper females are fertile.

(Baskar et al., 2019)

Mutant embryos show defects in the coalescence phase of epithelial wound repair, showing a significant delay before contraction.

(Abreu-Blanco et al., 2012)

Eb1²/Eb1⁰⁴⁵²⁴ and Eb1²/Eb1⁵ escapers often hold their wings in abnormal positions, including downward, held up or parted. All of these flies are flightless, whether or not they hold their wings in a normal position.

Although Eb1²/Eb1⁰⁴⁵²⁴ flies walk in a coordinated way, once turned upside-down, they fail to recover the correct body position as promptly as wild-type flies; mutant flies often take more than two minutes to right themselves while recovery in wild type is less than a second.

(Elliott et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

5888

108478

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

1A4

(Roote, 1996.12.3)

DmEB1²

(Elliott et al., 2005)

Eb1²

(Titus et al., 2023)

eb1²

(Baskar et al., 2019, Abreu-Blanco et al., 2012)

l(2)04524²

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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