FB2024_03 , released June 25, 2024
Allele: Dmel\mwra
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General Information
Symbol
Dmel\mwra
Species
D. melanogaster
Name
FlyBase ID
FBal0056460
Feature type
allele
Associated gene
mwr
Associated Insertion(s)
P{lacW}mwra
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Rasooly, 1996)
Progenitor genotype
P{lacW}3-76a
(Rasooly, 1996)
Associated Insertion(s)
P{lacW}mwra
Cytology
Description

Insertion of a P{lacW} element.

(Rasooly, 1996)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females are completely sterile, eggs that are laid are grossly normal but fail to hatch. Females heterozygous with mwra excision alleles (mwr1, mwr2, mwr3 or mwr4) are nearly or completely sterile. Mutation impairs segregation of nonexchange chromosomes. Meiotic defect is in homologue recognition as the chromosomes appear to be misaligned on an intact spindle.

      (Rasooly, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      mwra is an enhancer of phenotype of nodDTW

      (Rasooly, 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Presence of mwra increases the rate of X chromosome nondisjunction seven fold in nodDTW heterozygous females, phenotype of Df(1)nod is not enhanced.

      (Rasooly, 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of P{lacW} insertion partially relieves the female sterile phenotype but excisions retain the dominant nodDTW enhancing activity.

      (Rasooly, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mwra
      Name Synonyms
      Secondary FlyBase IDs
        References (1)