FlyBase Allele Report: Dmel\nod[DTW]

General Information

Symbol

Dmel\nod^DTW

Species

D. melanogaster

Name

Dominant Ted Wright

FlyBase ID

FBal0013072

Feature type

allele

Associated gene

Dmel\nod

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Rasooly et al., 1991)

Mutagen

ethyl methanesulfonate

(Rasooly et al., 1994)

Progenitor genotype

Cytology

Description

Single base change in the mechanochemical domain which affects the highly conserved putative ATP-binding/hydrolysis domain. Nucleotide substitution: G352A. Amino acid replacement: S94N. It is unlikely there is an additional mutation in the regulatory region although this region was not sequenced.

(Rasooly et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,581,268..11,581,268 [+]

Nucleotide change:

G11581268A

Reported nucleotide change:

G352A

Amino acid change:

S94N | nod-PA; S94N | nod-PB

Reported amino acid change:

S94N

(Rasooly et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | dominant

(Rasooly, 1996, Rasooly et al., 1994)

abnormal meiotic cell cycle | dominant | female

(Apionishev et al., 2001)

abnormal meiotic cell cycle | female | cold sensitive

(Rasooly et al., 1991)

abnormal mitotic cell cycle

(Rasooly et al., 1991)

lethal | recessive | cold sensitive

(Rasooly et al., 1994, Rasooly et al., 1991)

Phenotype Manifest In

meiosis & nuclear chromosome | female

(Apionishev et al., 2001)

Detailed Description

Statement

Reference

Heterozygous females show high rates of nondisjunction (57%) for the 4th chromosome and 0.8% nondisjunction for the X chromosome.

(Apionishev et al., 2001)

Dominant meiotic phenotype varies with dosage and temperature: at 25^oC only non-exchange chromosomes undergo nondisjunction and loss, at lower temperatures segregation of both exchange and nonexchange chromosomes is affected.

(Rasooly, 1996)

Severe alleles of nod reduce the transmission of the Dp(1;f)1187 derivative P{PZ}8-23 more than weaker alleles (nod^DTW > nod^DR3 >= nod³).

(Murphy and Karpen, 1995)

Dominant meiotic mutation. The effect of E(DTW) is dose-dependent, one copy enhances the phenotype while two copies renders the fly nearly sterile.

(Rasooly, 1995)

Defects in meiotic and mitotic chromosome segregation. At 23.5^oC heterozygous females exhibit the meiotic defect of abnormal segregation of nonexchange chromosomes. At 18^oC in homozygous or heterozygous females the meiotic defect is more severe causing defects in the segregation of both exchange and nonexchange chromosomes. Homozygous and hemizygous males exhibit mitotic defects including somatic chromosome breakage and loss. A single dose of nod^DTW is not sufficient to cause cold sensitivity, whether or not wild type protein is present.

(Rasooly et al., 1991)

Reduced survival when raised at 17^oC compared with that when raised at 25^oC; the differences in survival at the two temperatures vary substantially among replicate crosses. embryonic lethal female-sterile at 16^oC

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mei-218¹, nod^DTW has abnormal meiotic cell cycle | female phenotype, suppressible by lwr⁰⁵⁴⁸⁶

(Apionishev et al., 2001)

nod^DTW has abnormal meiotic cell cycle | female phenotype, suppressible by lwr⁵/lwr[+]

(Apionishev et al., 2001)

nod^DTW has abnormal meiotic cell cycle | dominant | female phenotype, suppressible by lwr⁰⁵⁴⁸⁶/lwr[+]

(Apionishev et al., 2001)

Other

Statement

Reference

mei-218¹, nod^DTW has abnormal meiotic cell cycle | female phenotype

(Apionishev et al., 2001)

neb^TE8, nod^DTW has female sterile | dominant phenotype

(Ruden et al., 1997)

neb^TE12, nod^DTW has female sterile | dominant phenotype

(Ruden et al., 1997)

neb^TE20, nod^DTW has female sterile | dominant phenotype

(Ruden et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

nod^DTW has phenotype, enhanceable by mwr¹

(Rasooly, 1996)

nod^DTW has phenotype, enhanceable by mwr²

(Rasooly, 1996)

nod^DTW has phenotype, enhanceable by mwr³

(Rasooly, 1996)

nod^DTW has phenotype, enhanceable by mwr⁴

(Rasooly, 1996)

nod^DTW has phenotype, enhanceable by mwr^a

(Rasooly, 1996)

Suppressed by

Statement

Reference

mei-218¹, nod^DTW has meiosis & nuclear chromosome | female phenotype, suppressible by lwr⁰⁵⁴⁸⁶

(Apionishev et al., 2001)

mei-218¹, nod^DTW has oocyte & spindle phenotype, suppressible by lwr⁰⁵⁴⁸⁶

(Apionishev et al., 2001)

nod^DTW has meiosis & nuclear chromosome | female phenotype, suppressible by lwr⁰⁵⁴⁸⁶/lwr[+]

(Apionishev et al., 2001)

nod^DTW has meiosis & nuclear chromosome | female phenotype, suppressible by lwr⁵/lwr[+]

(Apionishev et al., 2001)

nod^DTW has phenotype, suppressible by lwr⁰⁵⁴⁸⁶

(Apionishev and Rasooly, 1997)

Other

Statement

Reference

mei-218¹, nod^DTW has meiosis & nuclear chromosome | female phenotype

(Apionishev et al., 2001)

mei-218¹, nod^DTW has oocyte & spindle phenotype

(Apionishev et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

lwr⁰⁵⁴⁸⁶ or lwr⁵ dominantly suppress the nondisjunction phenotype of nod^DTW females. nod^DTW mei-218¹ double homozygous females show 60% X chromosome nondisjunction and 63% 4th chromosome nondisjunction. Oocyte spindles are often frayed or oddly shaped, or multiple spindles are present. These defects are suppressed by lwr⁰⁵⁴⁸⁶/+.

(Apionishev et al., 2001)

Heterozygous females transheterozygous with neb^TE8, neb^TE12 or neb^TE20 are sterile.

(Ruden et al., 1997)

Presence of mwr^a increases the rate of X chromosome nondisjunction seven fold in nod^DTW heterozygous females.

(Rasooly, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

107039

nod^DTW f¹/Dp(1;Y)Bar^S/C(1)DX, y¹ f¹

Notes on Origin

Discoverer

Wright.

Comments

"l(1)TW6^cs" has been renamed nod^DTW.

(Rasooly et al., 1991)

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

M94188

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAC14452

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Nod^DTW

(Huo et al., 2007)

l(1)TW6^cs

(Rasooly et al., 1991)

nod⁸

nod^DTW

Name Synonyms

Dominant Ted Wright

(Rasooly et al., 1991)

Secondary FlyBase IDs

References (20)

Report Sections

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