FlyBase Allele Report: Dmel\wg[sev.PC]

General Information

Symbol

Dmel\wg^sev.PC

Species

D. melanogaster

Name

sevenless promoter construct of Cadigan

FlyBase ID

FBal0055788

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

P{sev-wg.C}

Also Known As

P[sev-wg]

Key Links

Transgenic product class

cDNA

(Cadigan and Nusse, 1996)

wild_type

(Cadigan and Nusse, 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Cadigan and Nusse, 1996)

wild_type

(Cadigan and Nusse, 1996)

Mutagen

in vitro construct

(Cadigan and Nusse, 1996, Cadigan and Nusse, 1995)

Progenitor genotype

Carried in construct

P{sev-wg.C}

Cytology

Description

XbaI-ClaI fragment of the wg cDNA is under the control of sev promoter and three tandem repeats of the sev enhancer.

(Cadigan and Nusse, 1996)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Cadigan and Nusse, 1996)

Phenotype Manifest In

interommatidial bristle

(Parker et al., 2002, Rousset et al., 2001, Cadigan and Nusse, 1996)

Detailed Description

Statement

Reference

Mutants lack interommatidial bristles.

(Parker et al., 2002)

wg^sev.PC flies have eyes missing their interommatidial bristles.

(Rousset et al., 2001)

Interommatidial bristles are almost completely missing. No other abnormality is detectable. The bristles are replaced with tertiary pigment cells. Clones in the eye that lack the transgene have bristles.

(Cadigan and Nusse, 1996)

Specific abnormality in eye development, completely lacking interommatidial bristles.

(Cadigan and Nusse, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

wg^sev.PC has interommatidial bristle phenotype, suppressible by pygo^EP1076/Scer\GAL4^GMR.PF

(Parker et al., 2002)

wg^sev.PC has interommatidial bristle phenotype, suppressible by sgg^EP1576/Scer\GAL4^GMR.PF

(Parker et al., 2002)

wg^sev.PC has interommatidial bristle | cell autonomous phenotype, suppressible by Scer\GAL4^GMR.PF/fz2^{ECD.GPI.UAS.Tag:MYC}

(Rousset et al., 2001)

wg^sev.PC has interommatidial bristle phenotype, suppressible by nkd^UAS.Tag:MYC/Scer\GAL4^GMR.PF

(Rousset et al., 2001)

wg^sev.PC has phenotype, suppressible by N^l1N-ts1

(Cadigan and Nusse, 1996)

wg^sev.PC has phenotype, suppressible by sgg^A.hs

(Cadigan and Nusse, 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of sgg (sgg^A.hs), and removal of N (N^l1N-ts1) and Dl (Dl^6E/Dl^RF) activity can suppress the P{sev-wg.C} phenotype.

(Cadigan and Nusse, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wg^sev.PC

Name Synonyms

sevenless promoter construct of Cadigan

(Cadigan and Nusse, 1996)

Secondary FlyBase IDs

FBal0036016

References (6)

Report Sections

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