FB2024_03 , released June 25, 2024
Allele: Dmel\SxlcF1.otu
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General Information
Symbol
Dmel\SxlcF1.otu
Species
D. melanogaster
Name
FlyBase ID
FBal0051862
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
P{otu-Sxl.cF1}
Also Known As
P{otu::SxlcDNA}
Key Links
Transgenic product class
cDNA
(Hager and Cline, 1997)
wild_type
(Hager and Cline, 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hager and Cline, 1997)
wild_type
(Hager and Cline, 1997)
Mutagen
in vitro construct
(Hager and Cline, 1997, Salz and Flickinger, 1996)
Progenitor genotype
Carried in construct
P{otu-Sxl.cF1}
Cytology
Description

578bp NotI-Asp718 fragment of the otu drives expression of the 1.8kb female Sxl cDNA, cF1.

(Hager and Cline, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
otu
Encoded product / tool
Sxl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  germ cell cancer
      modeled by snf148
      (Chau et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression generates testes displaying autoregulatory cysts.

      (Hager and Cline, 1997)

      P{otu-Sxl.cF1} suppresses snf's female lethal-synergistic interaction phenotype.

      (Salz and Flickinger, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      SxlcF1.otu is a suppressor of female sterile phenotype of snf1

      (Gawande et al., 2006, Hager and Cline, 1997)

      SxlcF1.otu is a suppressor of female sterile phenotype of snf148

      (Gawande et al., 2006, Nagengast et al., 2003)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      If snf148/snf148, SxlcF1.otu females are crossed with SxlfP7B0 males only 6% of her SxlfP7B0/+ daughters survive.

      (Nagengast et al., 2003)

      Expression suppresses the germline-autonomous female sterility of snf1 mutants.

      (Hager and Cline, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Ectopic Sxl protein triggers the female-specific Sxl RNA splicing feedback loop in male germ cells without disrupting spermatogenesis. Protein is also found in somatic tissue but it is irrelevant in generating autoregulatory germline cysts.

      (Hager and Cline, 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SxlcF1.otu
      Name Synonyms
      Secondary FlyBase IDs
        References (7)