FlyBase Allele Report: Dmel\HDAC1[3-10]

General Information

Symbol

Dmel\HDAC1^3-10

Species

D. melanogaster

Name

FlyBase ID

FBal0049828

Feature type

allele

Associated gene

Dmel\HDAC1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Gepner et al., 1996)

Progenitor genotype

Cytology

Description

Amino acid replacement: D174G.

(Zhu et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:4,627,975..4,627,975 [+]

Nucleotide change:

A4627975G

Amino acid change:

D174G | HDAC1-PA

Reported amino acid change:

D174G

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhu et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | somatic clone

(Zhu et al., 2008)

abnormal mitotic cell cycle | somatic clone (with HDAC1^X5)

(Zhu et al., 2008)

decreased cell number | somatic clone

(Zhu et al., 2008)

decreased cell number | somatic clone (with HDAC1^X5)

(Zhu et al., 2008)

decreased occurrence of cell division | larval stage (with HDAC1^X5)

(Zhu et al., 2008)

increased cell death | somatic clone

(Zhu et al., 2008)

lethal | recessive

(Gepner et al., 1996)

lethal - all die before end of pupal stage (with HDAC1^X5)

(Zhu et al., 2008)

lethal - all die before end of second instar larval stage

(Zhu et al., 2008)

lethal - all die before end of second instar larval stage (with HDAC1^5-5)

(Zhu et al., 2008)

some die during pupal stage (with HDAC1^X5)

(Zhu et al., 2008)

some die during second instar larval stage

(Zhu et al., 2008)

some die during second instar larval stage (with HDAC1^5-5)

(Zhu et al., 2008)

Phenotype Manifest In

wing disc | somatic clone

(Zhu et al., 2008)

wing disc | somatic clone (with HDAC1^X5)

(Zhu et al., 2008)

Detailed Description

Statement

Reference

Rpd3^3-10 homozygous and Rpd3^5-5/Rpd3^3-10 transheterozygous mutants fail to survive beyond the end of the second larval instar stage.

Rpd3^3-10 wing disc clones are significantly smaller than their wild-type twinspots. A subset of the cells in the clone stain with apoptotic markers, indicating some degree of apoptotic induction.

Rpd3^X5/Rpd3^3-10 mutant larvae survive until the pupal stage. Wing discs are dramatically reduced in size compared to wild-type. This reduction in size appears to be due to a proliferation defect.

(Zhu et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

HDAC1^3-10, ttk^rM730 has visible phenotype, enhanceable by Mi-2⁴/Mi-2[+]

(Murawsky et al., 2001)

Other

Statement

Reference

HDAC1^3-10, ttk^rM730 has visible phenotype

(Murawsky et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

HDAC1^3-10, ttk^rM730 has wing sensillum | ectopic phenotype, enhanceable by Mi-2⁴/Mi-2[+]

(Murawsky et al., 2001)

Other

Statement

Reference

HDAC1^3-10, ttk^rM730 has wing sensillum | ectopic phenotype

(Murawsky et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for Rpd3^5-5 significantly suppresses In(1)w^m4 eye colour variegation.

Hdac3^6C/Rpd3^3-10 double mutants show complete suppression of In(1)w^m4 eye colour variegation.

(Zhu et al., 2008)

ttk^rM730 Rpd3^3-10 double mutants have ectopic sensory bristles on the wing veins.

(Murawsky et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

HDAC1^3-10

Rpd3^3-10

hdac1^m3-10

(Zhu et al., 2008)

l(3)64Cc^3-10

(Gepner et al., 1996)

rpd3^m3-10

(Murawsky et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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