FB2024_03 , released June 25, 2024
Allele: Dmel\inscP49
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General Information
Symbol
Dmel\inscP49
Species
D. melanogaster
Name
FlyBase ID
FBal0049667
Feature type
allele
Associated gene
Dmel\insc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Kraut et al., 1996)

loss of function allele

(Carmena et al., 1998, Li et al., 1997, Kraut and Campos-Ortega, 1996)
Mutagen
Delta2-3 transposase
(Kraut and Campos-Ortega, 1996)
Progenitor genotype
inscAB44
(Carmena et al., 1998, Kraut and Campos-Ortega, 1996)
Caused by aberration
Df(2R)inscP49
Cytology

Polytene chromosomes normal.

(Kraut and Campos-Ortega, 1996)
Description

Deletion removing about 9kb including the site of insertion of the P-element in inscAB44 and part of the transcribed region.

(Kraut and Campos-Ortega, 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dorsal oblique muscle cell

      (Carmena et al., 1998)

      embryonic/larval somatic muscle cell

      (Knirr et al., 1997)

      hypodermal muscle cell of larval abdominal 9

      (Carmena et al., 1998)

      muscle cell of abdominal 1 dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 1 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 1 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 1 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 2 dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 2 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 2 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 2 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 3 dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 3 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 3 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 3 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 4 dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 4 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 4 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 4 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 5 dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 5 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 5 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 5 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 6 dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 6 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 6 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 6 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 7 dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 7 dorsal acute muscle 3

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 7 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of abdominal 7 dorsal oblique muscle 5

      (Crozatier and Vincent, 1999)

      muscle cell of abdominal 8 dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of mesothoracic dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of mesothoracic dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of metathoracic dorsal acute muscle 1

      (Carmena et al., 1998)

      muscle cell of metathoracic dorsal oblique muscle 1

      (Carmena et al., 1998)

      muscle cell of prothoracic dorsal oblique muscle 1

      (Carmena et al., 1998)

      pericardial cell | embryonic stage

      (Carmena et al., 1998, Knirr et al., 1997)
      Detailed Description
      Statement
      Reference

      inscP49 mutant MP2 clones display wild-type morphology and development.

      (Rath et al., 2002)

      In mutant embryos the DA3A muscle is duplicated at the expense of DO5A in most segments.

      (Crozatier and Vincent, 1999)

      Approximately 30% of hemisegments produce an extra DA1 muscle in homozygous embryos. There is an approximately 60% reduction in the number of eve-expressing pericardial cells. An additional dorsal oblique muscle is observed in approximately 40-50% of hemisegments, which is likely to be DO1 in many cases. The founder cell of the DA1 muscle (FDA1) and its sibling (FDA1sib) both adopt an FDA1-like identity. The founder cell of the DO1 muscle (FDO1) is duplicated at the expense of its sibling (FDO1sib). numb3 inscP49 embryos have a qualitatively similar phenotype to numb3 embryos, although they exhibit these phenotypes at higher expressivity.

      (Carmena et al., 1998)

      Muscle and pericardial cell defects.

      (Knirr et al., 1997)

      Phenotypically similar to Df(2R)P72.

      (Kraut and Campos-Ortega, 1996)

      Defective in orientation of the mitotic spindle.

      (Kraut et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      insc[+]/inscP49, wtsx1 has abnormal neuroanatomy | embryonic stage phenotype

      (Keder et al., 2015)
      Phenotype Manifest In
      Other
      Statement
      Reference

      insc[+]/inscP49, wtsx1 has larval RP2 motor neuron | embryonic stage phenotype

      (Keder et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in wtsx1/+;inscP49/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

      (Keder et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      inscP49
      (Keder et al., 2015, Christensen et al., 2007.10.29, Griffiths et al., 2007, Rath et al., 2002)
      nemP49
      Name Synonyms
      Secondary FlyBase IDs
        References (18)