FB2024_03 , released June 25, 2024
Allele: Dmel\inschs.PK
Open Close
General Information
Symbol
Dmel\inschs.PK
Species
D. melanogaster
Name
heat shock construct of Kraut
FlyBase ID
FBal0086539
Feature type
allele
Associated gene
Dmel\insc
Associated Insertion(s)
Carried in Construct
P{hs-insc.K}
Key Links
Transgenic product class
cDNA
(Carmena et al., 1998)
wild_type
(Carmena et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Carmena et al., 1998)
wild_type
(Carmena et al., 1998)
Mutagen
in vitro construct
(Carmena et al., 1998)
Progenitor genotype
Carried in construct
P{hs-insc.K}
Cytology
Description

Full length insc cDNA is expressed under the control of an Hsp70 promoter.

(Carmena et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
insc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      ectoderm & embryo & spindle

      (Tio et al., 1999)
      Detailed Description
      Statement
      Reference

      Ectodermal cells of embryos ectopically expressing inschs.PK show reorientation of their mitotic spindles so that they are perpendicular to the apical surface of the embryo.

      (Tio et al., 1999)

      Ectopic expression of inschs.PK in a wild-type background has no effect on the development of the somatic muscles or the eve-expressing pericardial cells.

      (Carmena et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      inschs.PK rescues insc22

      (Tio et al., 1999)
      Partially rescues

      inschs.PK partially rescues inscP49

      (Carmena et al., 1998)
      Comments

      The RP2 neuron duplication phenotype of insc22 embryos is largely rescued by inschs.PK.

      (Tio et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      R. Kraut.

      (Carmena et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      inschs.PK
      Name Synonyms
      heat shock construct of Kraut
      (Carmena et al., 1998)
      Secondary FlyBase IDs
        References (2)