FB2024_03 , released June 25, 2024
Allele: Dmel\inscP8
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General Information
Symbol
Dmel\inscP8
Species
D. melanogaster
Name
FlyBase ID
FBal0046162
Feature type
allele
Associated gene
Dmel\insc
Associated Insertion(s)
P{hsneo}inscP8
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Knirr, 1996.4.30, Burchard et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{hsneo}inscP8
Cytology
Description

P{hsneo} insertion within the transcribed leader region, 13bp downstream of the transcription start site.

(Knirr et al., 1997)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      chordotonal organ

      (Burchard et al., 1995)

      embryonic/larval somatic muscle cell

      (Knirr et al., 1997)

      muscle cell of abdominal 1 dorsal oblique muscle 4

      (Burchard et al., 1995)

      muscle cell of abdominal 1 dorsal transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 1 lateral transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 1 lateral transverse muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 1 lateral transverse muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 2 dorsal oblique muscle 4

      (Burchard et al., 1995)

      muscle cell of abdominal 2 dorsal transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 2 lateral transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 2 lateral transverse muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 2 lateral transverse muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 3 dorsal oblique muscle 4

      (Burchard et al., 1995)

      muscle cell of abdominal 3 dorsal transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 3 lateral transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 3 lateral transverse muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 3 lateral transverse muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 4 dorsal oblique muscle 4

      (Burchard et al., 1995)

      muscle cell of abdominal 4 dorsal transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 4 lateral transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 4 lateral transverse muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 4 lateral transverse muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 5 dorsal oblique muscle 4

      (Burchard et al., 1995)

      muscle cell of abdominal 5 dorsal transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 5 lateral transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 5 lateral transverse muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 5 lateral transverse muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 6 dorsal oblique muscle 4

      (Burchard et al., 1995)

      muscle cell of abdominal 6 dorsal transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 6 lateral transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 6 lateral transverse muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 6 lateral transverse muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 7 dorsal oblique muscle 4

      (Burchard et al., 1995)

      muscle cell of abdominal 7 dorsal transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 7 lateral transverse muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 7 lateral transverse muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 7 lateral transverse muscle 3

      (Burchard et al., 1995)

      muscle cell of mesothoracic lateral longitudinal muscle 1

      (Burchard et al., 1995)

      pericardial cell | embryonic stage

      (Knirr et al., 1997)
      Detailed Description
      Statement
      Reference

      Embryonic muscle loss is due to defects in early somatic differentiation. Severe abnormalities are observed in a subset of pericardial cells.

      (Knirr et al., 1997)

      Embryos fail to build the normal pattern of somatic muscles.

      (Knirr et al., 1996)

      Some somatic muscles are missing and the chordotonal organs of the PNS are distorted, visceral mesoderm and the dorsal vessel are not disturbed. Pattern formation of the cuticle is normal suggesting the observed muscle phenotype is not a consequence of epidermis defects.

      (Burchard et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mobilisation of the P{hsneo} insertion reverts the lethal phenotype to viable, insertion is thought to be responsible for the mutation.

      (Burchard et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      inscP8
      l(2)neo113
      (Paululat et al., 1995)
      nemP8
      neo113
      (Burchard et al., 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)