FlyBase Allele Report: Dmel\enc[UU3]

General Information

Symbol

Dmel\enc^UU3

Species

D. melanogaster

Name

FlyBase ID

FBal0049476

Feature type

allele

Associated gene

Dmel\enc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

heat sensitive gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

heat sensitive gain of function allele

(Hawkins et al., 1996)

Mutagen

ethyl methanesulfonate

(Hawkins et al., 1997, Hawkins et al., 1996)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Van Buskirk and Schupbach, 2002)

abnormal mitotic cell cycle | recessive | heat sensitive

(Hawkins et al., 1996)

female sterile | recessive | cold sensitive

(Hawkins et al., 1996)

Phenotype Manifest In

dorsal appendage

(Van Buskirk et al., 2000)

egg chamber

(Van Buskirk and Schupbach, 2002, Van Buskirk et al., 2000, Hawkins et al., 1996)

karyosome

(Van Buskirk et al., 2000)

nurse cell

(Hawkins et al., 1996)

oocyte nucleus

(Hawkins et al., 1996)

Detailed Description

Statement

Reference

Most egg chambers have 32 germline cells in mutant females.

(Van Buskirk and Schupbach, 2002)

A fraction of mutant egg chambers contain oocytes in which the karyosome has a less compact appearance than usual. Many egg chambers have undergone an extra germline division. 12.2% of eggs derived from homozygous females raised at room temperature have little or no dorsal appendage material, 73.9% have a single dorsal appendage and 13.9% have two dorsal appendages.

(Van Buskirk et al., 2000)

Egg chambers exhibit doubling of the number of nurse cells, or in a small number of cases the egg chambers are bipolar or have less than 15 nurse cells. Phenotype is more severe at 25^oC. At 18^oC in the egg chambers that have the normal number of nurse cells the oocyte nucleus is enlarged (highly polyploid) and has a roughened appearance.

(Hawkins et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

enc^UU3 has abnormal mitotic cell cycle phenotype, suppressible by otu[+]/otu¹¹

(Van Buskirk and Schupbach, 2002)

enc^UU3 has abnormal mitotic cell cycle phenotype, suppressible by otu[+]/otu¹

(Van Buskirk and Schupbach, 2002)

enc^UU3 has abnormal mitotic cell cycle phenotype, suppressible by otu[+]/otu⁷

(Van Buskirk and Schupbach, 2002)

NOT suppressed by

Statement

Reference

enc^UU3 has abnormal mitotic cell cycle phenotype, non-suppressible by otu[+]/otu⁴

(Van Buskirk and Schupbach, 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

enc^UU3 has egg chamber phenotype, suppressible by otu[+]/otu¹¹

(Van Buskirk and Schupbach, 2002)

enc^UU3 has egg chamber phenotype, suppressible by otu[+]/otu¹

(Van Buskirk and Schupbach, 2002)

enc^UU3 has egg chamber phenotype, suppressible by otu[+]/otu⁷

(Van Buskirk and Schupbach, 2002)

NOT suppressed by

Statement

Reference

enc^UU3 has egg chamber phenotype, non-suppressible by otu[+]/otu⁴

(Van Buskirk and Schupbach, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The extra germline cell phenotype seen in enc^UU3 egg chambers is suppressed by otu⁷/+, otu¹/+ and otu¹¹/+ (suppression is strongest with otu¹¹).

(Van Buskirk and Schupbach, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

enc^UU3 is partially rescued by enc^Hsp83.PVB

(Van Buskirk et al., 2000)

Comments

enc^Hsp83.PVB rescues the mitotic defect (extra germline division) seen in enc^UU3 females. The cold-sensitive ventralised egg defect (loss of dorsal appendage material) of enc^UU3 females is partially rescued by enc^Hsp83.PVB.

(Van Buskirk et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

enc^UU3

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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