FlyBase Allele Report: Dmel\βggt-I[S-2554]

General Information

Symbol

Dmel\βggt-I^S-2554

Species

D. melanogaster

Name

FlyBase ID

FBal0047963

Feature type

allele

Associated gene

Dmel\βggt-I

Associated Insertion(s)

Carried in Construct

Also Known As

βggt-I^XS-2554

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Karim et al., 1996)

Progenitor genotype

Cytology

Description

Small deletion that removes the first exon and part of the 5' regulatory sequences.

(Therrien et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Karim et al., 1996, Therrien et al., 1995)

Phenotype Manifest In

cardioblast

(Yi et al., 2006)

embryonic pericardial cell

(Yi et al., 2006)

Detailed Description

Statement

Reference

At least 30% of homozygous stage 17 embryos show a "broken hearted" phenotype; the pericardial cells are dissociated from cardioblasts in the dorsal vessel.

(Yi et al., 2006)

Dominantly suppresses the rough eye phenotype of Ras85D^V12.sev.

(Therrien et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

βggt-I^S-2554 is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

βggt-I^S-2554, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Suppressor of

Statement

Reference

βggt-I^S-2554 is a suppressor of phenotype of Ras85D^V12.sev

(Karim et al., 1996)

βggt-I^S-2554 is a suppressor of eye phenotype of Ras85D^V12.sev

(Therrien et al., 1995)

NOT Suppressor of

Statement

Reference

βggt-I^S-2554/betaggt-I[+] is a non-suppressor of primordial germ cell | maternal effect | embryonic stage 5 phenotype of Neurl4^Δ1

(Jones and Macdonald, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by βggt-I^S-2554.

(Maixner et al., 1998)

Suppresses the rough eye phenotype of Ras85D^V12.sev. Suppresses the phenotype of Ras85D^N17.sev. Has little or no effect on the phenotype of phl::tor^13D.hs.sev. Has little or no effect on the phenotype of Ras85D::Src64B^{V12.ΔCAAX.sev}. Enhances the lethality of phl¹². Enhances the phl¹² eye phenotype. Has little or no effect on the Dsor1^XS520 eye phenotype. Has little or no effect on the aop^S2382 eye phenotype.

(Karim et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5681

βggt-I^S-2554/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

betaggt-I^S-2554

(Sawyer et al., 2020, Christensen et al., 2009.5.6)

βGGT-I^S-2554

(Yi, 2006, Yi et al., 2006)

βggt-I^S-2554

βggt-I^XS-2554

(Maixner et al., 1998, Karim et al., 1996)

βggt^xs2554

(Jones and Macdonald, 2015)

Name Synonyms

Secondary FlyBase IDs

FBal0047966

References (11)

Report Sections

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