FlyBase Allele Report: Dmel\wts[P8]

General Information

Symbol

Dmel\wts^P8

Species

D. melanogaster

Name

FlyBase ID

FBal0044516

Feature type

allele

Associated gene

Dmel\wts

Associated Insertion(s)

P{lacW}wts^P8

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Justice et al., 1995)

Progenitor genotype

P{lacW}P509-19

(Justice et al., 1995)

Associated Insertion(s)

P{lacW}wts^P8

Cytology

Description

Deletion of DNA flanking the wts^P509-19 P{lacW} insertion, probably in the proximal direction, without loss of the distal P{lacW} sequences.

(Justice et al., 1995)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEC

(Tao et al., 1999)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of carcinoma

is ameliorated by Cdk1^B47

(Tao et al., 1999)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Tao et al., 1999)

hyperplasia

(Tao et al., 1999)

increased occurrence of cell division | embryonic stage | somatic clone

(Justice et al., 1995)

lethal | recessive

(Justice et al., 1995)

lethal - all die before end of pupal stage | recessive

(Tao et al., 1999)

some die during pupal stage | recessive

(Tao et al., 1999)

Phenotype Manifest In

cuticle | embryonic stage | somatic clone

(Justice et al., 1995)

eye

(Tao et al., 1999)

Detailed Description

Statement

Reference

Homozygotes die as pupae. Eyes are typically rough and show overproliferation.

(Tao et al., 1999)

Homozygotes exhibit embryonic or early larval lethality. wts tumour phenotype in mitotic clones: overproliferation and apical hypertrophy of epithelial cells leading to abnormal deposition of cuticle.

(Justice et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

wts^P8 has hyperplasia phenotype, suppressible by CycA⁵

(Tao et al., 1999)

Other

Statement

Reference

Cdk1^B47, wts^P8 has viable phenotype

(Tao et al., 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

wts^P8 has eye phenotype, suppressible by CycA⁵

(Tao et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The lethality and overproliferation phenotype are rescued if the fly carries one copy of cdc2^B47 or CycA⁵.

(Tao et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

lats^P8

(Tao et al., 1999)

wts^P8

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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