FB2024_03 , released June 25, 2024
Allele: Dmel\enaGC8
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General Information
Symbol
Dmel\enaGC8
Species
D. melanogaster
Name
FlyBase ID
FBal0043045
Feature type
allele
Associated gene
Dmel\ena
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Gertler et al., 1995)
Progenitor genotype
Caused by aberration
Df(2R)enaGC8
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      enaGC5/enaGC8 embryos show modest levels of midline crossing errors by axons in the central nervous system.

      (Wills et al., 2002)

      29% of ISNb axons show a bypass phenotype in enaGC5/enaGC8 embryos. A small number of RP neurons follow an aberrant path within the central nervous system. 7% of ISNb axons show a bypass phenotype in enaGC8/+ embryos.

      (Wills et al., 1999)

      Heterozygotes with enaGC1 have diffuse and loosely bundled longitudinal and commissural axon tracts. Some heterozygotes with enaGC5 also exhibit axon misguiding. Some homozygous embryos exhibit thinning of longitudinal connectives, increased number of axons exciting the CNS from the longitudinal axons or failure of commissural axons to separate into anterior and posterior axon bundles. The overall organisation of the PNS is disrupted, spacing and organisation of the neurons is irregular and some clusters of neurons are mislocalised.

      (Gertler et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      robo[+], ena[+], enaGC8, robo15 is an enhancer of larval longitudinal connective phenotype of sli1

      (Bashaw et al., 2000)

      ena[+]/enaGC8 is an enhancer of larval longitudinal connective phenotype of robo15, sli[+]/sli1

      (Bashaw et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ena46

      (Gao et al., 1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      enaGC8
      enbGC8
      Name Synonyms
      Secondary FlyBase IDs
        References (8)