FB2024_03 , released June 25, 2024
Allele: Dmel\zipmhc-c2.1
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General Information
Symbol
Dmel\zipmhc-c2.1
Species
D. melanogaster
Name
FlyBase ID
FBal0036096
Feature type
allele
Associated gene
Dmel\zip
Associated Insertion(s)
Carried in Construct
Also Known As
zip2.1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Young et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones result in wing defects including vein expansion, blisters and necrotic regions.

      (Franke et al., 2010)

      Lethality acts post-embryonically. Produces malformed phenotype when in double heterozygosis with second site zip non-complementing mutants.

      (Halsell and Kiehart, 1998)

      Embryos fail to complete dorsal closure as the mutant myosin fails to contribute sufficient myosin to drive dorsal closure to completion.

      (Young et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      zipmhc-c2.1 is a non-suppressor of Malpighian tubule phenotype of raw1

      (Blake et al., 1999)

      zipmhc-c2.1 is a non-suppressor of embryonic/larval salivary gland | embryonic stage phenotype of raw1

      (Blake et al., 1999)

      zipmhc-c2.1 is a non-suppressor of Malpighian tubule phenotype of rib1

      (Blake et al., 1999)

      zipmhc-c2.1 is a non-suppressor of embryonic/larval salivary gland | embryonic stage phenotype of rib1

      (Blake et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Does not suppress the salivary gland or Malpighian tubule phenotypes of raw1 and rib1.

      (Blake et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      zip2.1
      (Franke et al., 2010, Williams et al., 2001, Blake et al., 1999, Blake et al., 1998, Halsell and Kiehart, 1998)
      zipmhc-c2.1
      Name Synonyms
      Secondary FlyBase IDs
        References (6)