FB2024_03 , released June 25, 2024
Allele: Dmel\su(Hw)J
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General Information
Symbol
Dmel\su(Hw)J
Species
D. melanogaster
Name
FlyBase ID
FBal0035729
Feature type
allele
Associated gene
Dmel\su(Hw)
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Smith and Corces, 1995, Harrison et al., 1993)
Progenitor genotype
Cytology
Description

Lacks homology regions B and C as well as the carboxy-terminal acidic domain.

(Gdula and Corces, 1997)

Loss of the 149 carboxy-terminal amino acids of the su(Hw) protein.

(Georgiev and Kozycina, 1996)

Deletion of the carboxy-terminal acidic domain.

(Gerasimova et al., 1995)

Deletion of the terminal 149 residues, including the carboxy-terminal acidic domain and a large hydrophobic region adjacent to the leucine zipper domain.

(Smith and Corces, 1995)

Nucleotide substitution: G3318T. Nonsense mutation causing loss of the terminal 149 amino acids.

(Harrison et al., 1993)

Deletion of an acidic domain.

(Georgiev and Kozitsina, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:14,305,248..14,305,248 [-]
Nucleotide change:

G14305248T

Reported nucleotide change:

G3318T

Amino acid change:

E796term | su(Hw)-PA; E796term | su(Hw)-PB; E796term | su(Hw)-PC

Reported amino acid change:

??term

Comment:

Reported nucleotide numbering from FBrf0048095.

(Harrison et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      su(Hw)J cancels the effect of mod(mdg4)ul on trans repression of y gene expression.

      (Georgiev and Corces, 1995)

      Weak suppression of y2 phenotype.

      (Harrison et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      su(Hw)J is a suppressor of visible phenotype of scme

      (Golovnin et al., 1999)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      su(Hw)J is a suppressor of phenotype of mod(mdg4)ul

      (Georgiev and Kozycina, 1996)

      su(Hw)J is a suppressor of phenotype of y2

      (Gerasimova et al., 1995)
      NOT Suppressor of
      Statement
      Reference

      su(Hw)J is a non-suppressor of phenotype of y2

      (Gerasimova et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The scme bristle phenotype is slightly suppressed by su(Hw)J.

      (Golovnin et al., 1999)

      Has no effect on the y phenotype of y2, y2PR1 or y2PR2. But homozygous su(Hw)J or su(Hw)J/+ completely suppresses the inhibitory effect of mod(mdg4)ul on y expression in bristles, though body and wings are less affected. Strongly suppresses the inhibitory effect of mod(mdg4)ul in y2/y59b.

      (Georgiev and Kozycina, 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong su(Hw) allele.

      (Georgiev and Corces, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      su(Hw)J
      su(Hw)j
      (Golovnin et al., 2005, Golovnin et al., 1999, Georgiev and Kozycina, 1996, Georgiev and Kozitsina, 1992)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0035734
      References (9)