FB2024_03 , released June 25, 2024
Allele: Dmel\rux+t6.0
Open Close
General Information
Symbol
Dmel\rux+t6.0
Species
D. melanogaster
Name
FlyBase ID
FBal0035527
Feature type
allele
Associated gene
Dmel\rux
Associated Insertion(s)
Carried in Construct
P{rux}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Thomas et al., 1994)
wild_type
(Thomas et al., 1994)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Thomas et al., 1994)
wild_type
(Thomas et al., 1994)
Mutagen
in vitro construct
(Secombe et al., 1998, Thomas et al., 1994)
Progenitor genotype
Carried in construct
P{rux}
Cytology
Description

6.0kb StuI-EcoRI genomic fragment that includes the rux transcription unit.

(Thomas et al., 1994)
Allele components
Component
Use(s)
Regulatory region(s)
rux
Encoded product / tool
rux
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
X:6,032,578..6,038,126 [-]
Linked to:
StuI-EcoRI restriction fragment
(Thomas et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Male germ cells with excess rux function execute only one division at meiosis resulting in cysts of 32, rather than 64, germ cells. The division that does occur is a meiosis I rather than a meiosis II division.

      (Gonczy et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      rux+t6.0 is an enhancer of visible | recessive phenotype of CycEJP

      (Secombe et al., 1998)

      rux+t6.0 is an enhancer of decreased occurrence of cell division | larval stage phenotype of CycEJP

      (Secombe et al., 1998)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      rux+t6.0 is an enhancer of eye phenotype of CycEJP

      (Secombe et al., 1998)

      rux+t6.0 is an enhancer of eye disc posterior to the morphogenetic furrow | larval stage phenotype of CycEJP

      (Secombe et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Enhances the rough eye phenotype of CycEJP homozygotes. One copy of rux+t6.0 has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycEJP homozygotes.

      (Secombe et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      rux+t6.0 rescues rux4

      (Thomas et al., 1994)

      rux+t6.0 rescues rux3

      (Thomas et al., 1994)

      rux+t6.0 rescues rux8

      (Thomas et al., 1994)
      Comments

      Rescues the rough-eye phenotype of rux3, rux4 and rux8 and the sterility of rux8.

      (Thomas et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rux+t6.0
      Name Synonyms
      Secondary FlyBase IDs
        References (4)