FB2024_03 , released June 25, 2024
Allele: Dmel\fogRA67
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General Information
Symbol
Dmel\fogRA67
Species
D. melanogaster
Name
FlyBase ID
FBal0034625
Feature type
allele
Associated gene
Dmel\fog
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    No evidence of a deletion for, or break, in fog.

    (Costa, 1995.10.30)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        During stage 11 of embryogenesis, the salivary gland primordium of fkh6 homozygotes still forms an invagination pit, although frequently exhibiting a slight increase in width, still forms an apparently normal supra-cellular myosin cable, does not exhibit significant changes in circularity, and its cells still constrict apically, but frequently exhibits an abnormal ingression furrow along the edge, as compared to controls; the region to the anterior of the presumptive invagination site, however, fails to cluster the primordium cells with lower apical surface area, and these cells also only form small apical foci of myosin and Rok protein, as compared to controls. During later of oogenesis, this fogRA67-mutant primordium frequently exhibits internalization and migration defects, including being partially or completely externalized, as compared to controls.

        (Chung et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Not rescued by

        fogRA67 is not rescued by Scer\GAL4fkh.PH/fogUAS.cDa

        (Chung et al., 2017)
        Comments

        fogRA67 homozygous embryos exhibit defects in salivary gland primordium internalization, which are not rescued by the expression of fogScer\UAS.cDa under the control of Scer\GAL4fkh.PH.

        (Chung et al., 2017)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        This allele was originally thought to be Df(1)RA67, but complementation and molecular analysis failed to reveal any evidence of a deletion.

        (Costa, 1995.10.30)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        fogRA67
        (Vishwakarma et al., 2022, Chung et al., 2017, Christensen et al., 2009.6.15)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)