FB2024_03 , released June 25, 2024
Allele: Dmel\fogUAS.cDa
Open Close
General Information
Symbol
Dmel\fogUAS.cDa
Species
D. melanogaster
Name
FlyBase ID
FBal0191858
Feature type
allele
Associated gene
Dmel\fog
Associated Insertion(s)
Carried in Construct
P{UAS-fog}
Also Known As
UAS-fog
Key Links
Transgenic product class
cDNA
(Dawes-Hoang et al., 2005)
wild_type
(Dawes-Hoang et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Dawes-Hoang et al., 2005)
wild_type
(Dawes-Hoang et al., 2005)
Mutagen
in vitro construct
(Dawes-Hoang et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-fog}
Cytology
Description

Full-length fog cDNA is placed downstream of UASt regulatory sequences.

(Dawes-Hoang et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
fog
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Maternal expression of fogUAS.cDa under the control of Scer\GAL4VP16.mat.αTub67C impairs the formation of the ventral midline during gastrulation, resulting in embryo twisting, abnormal cell constrictions, and incomplete midline closure.

      Expression under the control of Scer\GAL4Bx-MS1096 leads to the loss of most of the wing blade surface.

      (Chai et al., 2019)

      Expression of fogScer\UAS.cDa driven by Scer\GAL4mat.αTub67C.T:Hsim\VP16 increases smog vesicles in the mesoderm.

      (Kerridge et al., 2016)

      Scer\GAL4A9-mediated expression of fogScer\UAS.cDa leads to misfolding phenotypes in the wing disc and adult wing.

      (Manning et al., 2013)

      Expression of fogScer\UAS.cDa, under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in embryos taking approximately 1.4 times longer to complete ventral furrow formation compared to control embryos. Expression of fogScer\UAS.cDa, under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in apical flattening. In addition, the apical shift of adherens junctions, that occurs normally in the ventral furrow region, also occurs in more lateral and dorsal cells, and these junctions are more tightly condensed than the equivalent junctions of control embryos.

      (Dawes-Hoang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of mthl1KK111116 substantially rescues the the misfolding phenotypes induced by Scer\GAL4A9-mediated expression of fogScer\UAS.cDa in the wing disc and adult wing.

      (Manning et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4fkh.PH/fogUAS.cDa fails to rescue fogRA67

      (Chung et al., 2017)
      Comments

      The expression of fogScer\UAS.cDa under the control of Scer\GAL4fkh.PH fails to rescue the salivary gland primordium internalization defects exhibited by fogRA67 homozygous embryos.

      (Chung et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fogScer\UAS.cDa
      fogUAS.cDa
      Name Synonyms
      Secondary FlyBase IDs
        References (9)