FB2024_03 , released June 25, 2024
Allele: Dmel\das22
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General Information
Symbol
Dmel\das22
Species
D. melanogaster
Name
FlyBase ID
FBal0034394
Feature type
allele
Associated gene
Dmel\da
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Grammont et al., 1997, Cummings and Cronmiller, 1994)
Mutagen
ethyl methanesulfonate
(Cummings and Cronmiller, 1994)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C1928T. Amino acid replacement: R568W.

(Baker and Cronmiller, 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:10,391,763..10,391,763 [+]
Nucleotide change:

C10391763T

Reported nucleotide change:

C1928T

Amino acid change:

R568W | da-PA; R568W | da-PB; R568W | da-PC; R568W | da-PD

Reported amino acid change:

R568W

Comment:

Mutation changes a basic residue located on the outer surface of helix I of the bHLH domain.

(Baker and Cronmiller, 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      das22/da7 females show a drastic reduction in apoptotic cells in the germarium compared to wild type.

      (Smith et al., 2002)

      Heteroallelic das22/da7 females show reduced fecundity: though 3-5 day old females deposited normal numbers of eggs, production drops precipitously after that. Egg chambers fail to bud off from the germarium, there is no morphological boundary between the germarium and the vitellarium. Interfollicular stalks are missing. Egg chambers are often compound, and are necrotic in mature ovarioles.

      (Cummings and Cronmiller, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      das22/da7 has ovary phenotype, non-suppressible by Su(dalyh)26H626H6

      (Smith and Cronmiller, 2001)
      Other
      Statement
      Reference

      da[+]/das22, stl8-1204 has ovariole phenotype

      (Smith and Cronmiller, 2001)

      das22, stl8-1204 has ovariole phenotype

      (Smith and Cronmiller, 2001)

      das22, toc[-] has ovary phenotype

      (Grammont et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      65% of das22 stl8-1204 double heterozygotes have ovariole defects.

      (Smith and Cronmiller, 2001)

      Transheterozygotes with toc alleles exhibit ovary defects.

      (Grammont et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Isolated in a mutagenesis screen for dominant maternal enhancers of the da1 female-specific maternal effect. Phenotype in mutant ovaries is not allele specific, but represents a da- phenotype.

      (Cummings and Cronmiller, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      daS22
      (Grammont et al., 1997)
      das22
      Name Synonyms
      Secondary FlyBase IDs
        References (5)