FB2024_03 , released June 25, 2024
Allele: Dmel\da7
Open Close
General Information
Symbol
Dmel\da7
Species
D. melanogaster
Name
FlyBase ID
FBal0002220
Feature type
allele
Associated gene
Dmel\da
Associated Insertion(s)
P{}da7
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Cummings and Cronmiller, 1994)
Mutagen
PM hybrid dysgenesis
Progenitor genotype
Associated Insertion(s)
P{}da7
Cytology
Description

P element insertion in untranslated leader

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      das22/da7 females show a drastic reduction in apoptotic cells in the germarium compared to wild type.

      (Smith et al., 2002)

      Heteroallelic das22/da7 females show reduced fecundity: though 3-5 day old females deposited normal numbers of eggs, production drops precipitously after that. Egg chambers fail to bud off from the germarium, there is no morphological boundary between the germarium and the vitellarium. Interfollicular stalks are missing. Egg chambers are often compound, and are necrotic in mature ovarioles.

      (Cummings and Cronmiller, 1994)

      viable; reduced viability with da1. lethal with da2, da3, Df, or da5

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      das22/da7 has ovary phenotype, non-suppressible by Su(dalyh)26H626H6

      (Smith and Cronmiller, 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Lethality of da2/da7 can be rescued by dahs.PSP, and females show same follicular phenotype as das22/da7.

      (Cummings and Cronmiller, 1994)

      partially complements da1 female lethal maternal effect.

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Phenotype in mutant ovaries is not allele specific, but represents a da- phenotype.

      (Cummings and Cronmiller, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      da7
      daPa
      Name Synonyms
      Secondary FlyBase IDs
        References (5)