FB2024_03 , released June 25, 2024
Allele: Dmel\Ca-α1DX7
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General Information
Symbol
Dmel\Ca-α1DX7
Species
D. melanogaster
Name
FlyBase ID
FBal0033486
Feature type
allele
Associated gene
Dmel\Ca-α1D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Roote, 1995.5.4)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ca-α1DX7 mutant males, but not females, show a significantly increased lifespan and a less severe age-dependent decline in locomotion, as compared to controls.

      Ca-α1DX7 mutants show decreased cardiac function, as shown by the significant decrease in fractional shortening, but not in heart rate, end diastolic diameter, end systolic diameter or arrhythmic index, as compared to controls.

      (Lam et al., 2018)

      Mutants die at the late embryonic stage with no gross morphological abnormalities. The tracheae of mutant embryos generally do not become gas-filled. Embryos do move but the movements are very weak: slow localised twitches, usually at the posterior end. Some peristaltic motion is visible in the gut, this is very slow. Occasionally embryos bend their heads but movement of the cephalopharyngeal apparatus is not seen. Pumping of the heart is not seen.

      (Eberl et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Ca-α1DX7/Ca-alpha1D[+] is a suppressor | partially of lethal phenotype of Cam7/Camn339

      (Wang et al., 2003)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Ca-α1DX7/Ca-alpha1D[+] is a suppressor | partially of pupa phenotype of Cam7/Camn339

      (Wang et al., 2003)
      Other
      Statement
      Reference

      Ca-α1DX7, Cam7/Camn339 has wing phenotype

      (Wang et al., 2003)

      Ca-α1DX7/Ca-alpha1D[+], Cam7/Camn339 has wing phenotype

      (Wang et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ca-α1DX7/+ has a slight suppressing effect on the Cam7/Camn339 phenotype; there is a small but significant increase in the pupal length:width ratio, but no obvious effect on pupal case indentations, and a small fraction of the animals eclose as weak, uncoordinated adults with no wing expansion.

      (Wang et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ca-α1DX7 is rescued by Ca-α1D+tCa01

      (Eberl et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      S. Roth.

      (Roote, 1995.5.4)
      Comments
      Comments

      Shows normal GABA staining in stage 17 nerve cord.

      (Kueppers et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ca-α1DX7
      (Lam et al., 2018, Terada et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)