FlyBase Allele Report: Dmel\dpp[hr92]

General Information

Symbol

Dmel\dpp^hr92

Species

D. melanogaster

Name

FlyBase ID

FBal0031071

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Arora and Nusslein-Volhard, 1992)

Mutagen

ethyl methanesulfonate

(Wharton et al., 1996, Wharton et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: C587Y.

(Wharton et al., 1996)

Mutation falls in the C-terminal ligand region of the dpp protein.

(Wharton et al., 1996)

Nucleotide substitution: G2947A.

(Wharton et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,458,553..2,458,553 [+]

Nucleotide change:

G2458553A

Reported nucleotide change:

G2947A

Amino acid change:

C587Y | dpp-PA; C587Y | dpp-PB; C587Y | dpp-PC; C587Y | dpp-PE

Reported amino acid change:

C587Y

(Wharton et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Wharton et al., 1993)

lethal - all die during embryonic stage

(Wharton et al., 1996)

some die during embryonic stage

(Wharton et al., 1996)

visible | adult stage | dominant

(Dahal et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

dpp^hr92/+ mutant wings show thickened, bifurcated veins.

(Dahal et al., 2012)

The hindgut of heterozygous and homozygous embryos is significantly shorter than that of wild-type embryos. In heterozygotes, the hindgut is associated with abnormally internalised anal pads. In homozygous embryos, the small intestine and rectum form normally, but the large intestine is very short.

(Takashima and Murakami, 2001)

Embryos show cuticular holes, disorganization of the head skeleton, internalization of the seventh and eighth abdominal segments and a thoracic constriction. The first and second ventral denticle belts are expanded up to the dorsal midline. The filzkorper are entirely absent.

(Wharton et al., 1996)

Survival of heterozygotes is reduced if also heterozygous for certain alleles of tld.

(Finelli et al., 1994)

Dominant lethality less than 50%. Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis.

(Wharton et al., 1993)

Moderate ventralised phenotype. Rings of ventral denticle belts differentiate around the entire dorsoventral axis, almost no dorsal hairs are seen and the antennal and maxillary sense organs are missing. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

(Arora and Nusslein-Volhard, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^hr92 has lethal | embryonic stage | recessive phenotype, enhanceable | maternal effect by Df(2L)C144/+

(Su et al., 2001)

dpp^hr92 has lethal | embryonic stage | recessive phenotype, enhanceable | maternal effect by Df(2L)DTD52-D51/+

(Su et al., 2001)

dpp^hr92 has lethal | embryonic stage | recessive phenotype, enhanceable | maternal effect by lilli^a16/lilli[+]

(Su et al., 2001)

dpp^hr92 has lethal | embryonic stage | recessive phenotype, enhanceable | maternal effect by T(2;3)DTD46.4/+

(Su et al., 2001)

Enhancer of

Statement

Reference

dpp[+]/dpp^hr92 is an enhancer of visible | adult stage phenotype of Irk2^DN.UAS, Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

NOT Enhancer of

Statement

Reference

dpp[+]/dpp^hr92 is a non-enhancer of visible | adult stage phenotype of Irk2^UAS.cDa, Scer\GAL4^da.G32

(Dahal et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^hr92 has phenotype, enhanceable by tld¹⁴

(Raftery et al., 1995)

Enhancer of

Statement

Reference

dpp[+]/dpp^hr92 is an enhancer of wing phenotype of Irk2^DN.UAS, Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

NOT Enhancer of

Statement

Reference

dpp[+]/dpp^hr92 is a non-enhancer of wing vein phenotype of Irk2^UAS.cDa, Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

Suppressor of

Statement

Reference

dpp[+]/dpp^hr92 is a suppressor | partially of germarium phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

dpp[+]/dpp^hr92 is a suppressor | partially of spectrosome phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

dpp^hr92 is a suppressor | partially of female germline stem cell | increased number phenotype of Su(var)3-3^ΔN

(Eliazer et al., 2011)

Other

Statement

Reference

Ack⁸⁶, dpp[+]/dpp^hr92 has embryo | dorsal closure stage phenotype

(Zahedi et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The increased number of spectrosome-containing cells in germaria characteristic for adult females expressing Cul2^GD8913 RNAi under the control of the Scer\GAL4^ptc.PU can be partially rescued by combination with either dpp^hr92, dpp^hr56 or tkv⁷ in a heterozygous state or by knocking-down dpp by co-expression of either dpp^JF01090 or dpp^JF01091 RNAi.

(Ayyub et al., 2015)

One copy of dpp^hr92 enhances the wing defects seen when Irk2^DN.Scer\UAS is expressed under the control of Scer\GAL4^Bx-MS1096. 84% of wings from female flies expressing the P{UAS-Irk2.DN}5.2 insertion line display defects, with 29% of these considered to be severe. When the stronger P{UAS-Irk2.DN}5.1 insertion line is expressed 97% of wings from female flies display severe defects.

One copy of dpp^hr92 does not enhance the wing vein defects seen when Irk2^Scer\UAS.cDa is expressed under the control of Scer\GAL4^Bx-MS1096.

(Dahal et al., 2012)

dpp^hr92/+ partially suppresses the Su(var)3-3^ΔN mutant supernumerary germline cell phenotype resulting in an increased number of germline cysts with branched fusomes and maturing egg chambers.

(Eliazer et al., 2011)

dpp^hr92/+ ; Ack⁸⁶/Ack⁸⁶ embryos show dorsal closure defects at a relatively low frequency, but which is significantly higher than the frequency seen in either dpp^hr92/+ or Ack⁸⁶/Ack⁸⁶ single mutant embryos.

(Zahedi et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2069

dpp^hr92 cn¹ bw¹/SM6a

Kyoto

106649

dpp^hr92 cn¹ bw¹/SM6a

Notes on Origin

Discoverer

Blackman.

(Wharton et al., 1993)

Comments

Based on considerations of degree of dominant lethality, dpp alleles can be placed in an allelic series. Progressing from weakest to most severe the series is: dpp^e87 < dpp^e90 < dpp^hr56 < dpp^hr4 < dpp^hr92 < dpp^hr27 < dpp^hr93 < dpp^H94 < dpp^H95 < dpp^H96 = dpp^H91 = dpp^H46.

(Wharton et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dpp⁹²

(Iwaki and Lengyel, 2002)

dpp^hr92

(Li et al., 2020, Dominguez et al., 2016, Ayyub et al., 2015, Hodar et al., 2014, Dahal et al., 2012, Eliazer et al., 2011, Pilgram et al., 2011, Zahedi et al., 2008, Bangi and Wharton, 2006, Scuderi et al., 2006)

hin-r92

(Arora and Nusslein-Volhard, 1992)

Name Synonyms

Secondary FlyBase IDs

References (22)

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