FlyBase Allele Report: Dmel\brn[fs.107]

General Information

Symbol

Dmel\brn^fs.107

Species

D. melanogaster

Name

FlyBase ID

FBal0030650

Feature type

allele

Associated gene

Dmel\brn

Associated Insertion(s)

Carried in Construct

Also Known As

brn^fs107

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:4,104,924..4,104,924 [+]

Nucleotide change:

T4104924A

Amino acid change:

Y147N | brn-PA

Reported amino acid change:

Y147N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Pizette et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

brn^fs.107 hemizygous and brn^fs.107/brn^l.6P6 larvae have significantly increased bouton number and satellite bouton number at the neuromuscular junction of muscle 4, compared to controls, with no effect on bouton size.

(Huang et al., 2018)

Females carrying toc mutants exhibit wild type ovary morphology.

(Grammont et al., 1997)

Eggs derived from homozygous females dispay dorsal appendages fused along the dorsal midline. Eggs derived from heterozygous mothers are completely wild type. The fused dorsal appendage is twice as wide as that of a single appendage.

(Goode et al., 1996)

Homozygous females lay eggs with fused dorsal appendages: embryos show neurogenic phenotypes. Dorsal appendage phenotype of brn^fs.107 is cold temperature sensitive and is more extreme than that of brn^l.6P6. Cold sensitive period is at stages 6-7 of oogenesis, coincident with first overt polarisation of the egg chamber.

(Goode et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

brn^fs.107 is a non-enhancer of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2009)

NOT Suppressor of

Statement

Reference

brn^fs.107 is a non-suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

brn^fs.107/brn^l.6P6 has follicle cell phenotype, enhanceable by da[+]/da²

(Smith et al., 2002)

brn^fs.107 has follicle cell phenotype, enhanceable by da[+]/da²

(Smith et al., 2002)

NOT Enhancer of

Statement

Reference

brn^fs.107 is a non-enhancer of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2009)

NOT Suppressor of

Statement

Reference

brn^fs.107 is a non-suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype caused by expression of H^Scer\UAS.cMa under the control of Scer\GAL4^GMR.PU is unaffected if the flies also carry brn^fs.107.

(Protzer et al., 2009)

brn^fs.107/brn⁺; grk^ED22/grk⁺ females display large gaps in the follicular epithelium, frequently uncovering over half of the egg chamber exposing the nurse cells. Eggs derived from these females display dorsal appendages fused at the base with two appendages apparent, indistinguishable from a weak brn eggshell phenotype (intermediate or strong ventralised phenotype).

(Morgan and Mahowald, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

4303

brn^fs.107 v²⁴/FM3

600470

brn^fs.107/FM6, w¹

600471

brn^fs.107 v²⁴ P{neoFRT}18A/FM6, w¹

Kyoto

107677

brn^fs.107 v²⁴/FM3

Notes on Origin

Discoverer

Comments

Allelic series in the ovary: brn²²⁸ > brn^l.6P6 (germline clones) = brn¹⁹⁸ > brn^fs.107. Zygotic requirement for brn alleles (strongest to weakest): brn^l.6P6 > brn²²⁸ > brn¹⁹⁸ > brn^fs.107.

(Swan et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

brn¹

brn^fs.107

(Eberwein et al., 2023, Cook and Cook, 2010.5.7, Cook and Cook, 2010.5.7, Cook et al., 2010.2.17, Cook et al., 2010.2.17, Popodi et al., 2010-, Protzer et al., 2009, Chen et al., 2007)

brn^fs107

(Huang et al., 2018, Swan et al., 2001)

fs(1)107

(Morgan and Mahowald, 1996, Perrimon et al., 1986)

fs(1)A107

(Goode et al., 1992)

fs(1)G107

fs.107

(Grammont et al., 1997)

Name Synonyms

Secondary FlyBase IDs

FBal0001301

References (17)

Report Sections

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