FlyBase Allele Report: Dmel\al[ice]

General Information

Symbol

Dmel\al^ice

Species

D. melanogaster

Name

alice

FlyBase ID

FBal0030482

Feature type

allele

Associated gene

Dmel\al

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Campbell et al., 1993)

loss of function allele

(Campbell, 2005)

Mutagen

ethyl methanesulfonate

(Campbell et al., 1993)

Progenitor genotype

Caused by aberration

Ab(2;?)al^ice

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage | recessive

(Pueyo et al., 2000)

some die during pharate adult stage | recessive

(Pueyo et al., 2000)

viable

(Campbell and Tomlinson, 1998)

visible

(Wehn and Campbell, 2006)

visible (with al^ex)

(Tsuji et al., 2000)

visible (with Df(2L)al)

(Couso and Bishop, 1998)

visible | recessive

(Campbell et al., 1993)

Phenotype Manifest In

arista

(Wehn and Campbell, 2006, Campbell, 2005, Campbell et al., 1993)

arista (with al^ex)

(Kojima et al., 2005, Tsuji et al., 2000)

leg

(Campbell, 2005)

leg | distal (with al^ex)

(Tsuji et al., 2000)

mesothoracic bristle (with al^ex)

(Kojima et al., 2005)

pretarsus (with Df(2L)al)

(Couso and Bishop, 1998)

scutellum

(Campbell et al., 1993)

sternopleural bristle

(Campbell et al., 1993)

sternopleural bristle (with Df(2L)al)

(Couso and Bishop, 1998)

unguis

(Campbell and Tomlinson, 1998, Campbell et al., 1993)

unguis (with al^ex)

(Kojima et al., 2005)

unguis (with Df(2L)al)

(Couso and Bishop, 1998)

wing vein L2

(Campbell et al., 1993)

Detailed Description

Statement

Reference

The arista is almost completely absent in mutant flies.

(Wehn and Campbell, 2006)

In al^ice mutant flies, the arista is reduced to a vestige.

(Campbell, 2005)

al^ice/al^ex flies are missing claws, the arista in the antenna and medial notum bristles.

(Kojima et al., 2005)

All pretarsus structures in the leg and the arista are lost in al^ex/al^ice flies.

(Tsuji et al., 2000)

Homozygous legs lack claws.

(Campbell and Tomlinson, 1998)

The 5th tarsal segment is reduced and the claw is missing in the legs of al^ice/Df(2L)al flies. The sternopleural bristles are missing.

(Couso and Bishop, 1998)

Phenotypically similar to al³ : the arista, tarsal claw and sternopleural bristles are absent, scutellum is reduced and the second wing vein is interrupted.

(Campbell et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

al^ice has lethal | pharate adult stage | recessive phenotype, enhanceable by Lim1^R12.4

(Pueyo et al., 2000)

Enhancer of

Statement

Reference

al^ice is an enhancer of lethal | pharate adult stage | recessive phenotype of Lim1^R12.4

(Pueyo et al., 2000)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

al^ice has pretarsus phenotype, non-enhanceable by C15²

(Campbell, 2005)

al^ice has unguis phenotype, non-enhanceable by C15²

(Campbell, 2005)

al^ice has arista phenotype, non-enhanceable by C15²

(Campbell, 2005)

al^ice has empodium phenotype, non-enhanceable by C15²

(Campbell, 2005)

al^ice has pulvillus phenotype, non-enhanceable by C15²

(Campbell, 2005)

al^ice has tarsal segment 4 phenotype, non-enhanceable by C15²

(Campbell, 2005)

NOT Enhancer of

Statement

Reference

al^ice is a non-enhancer of arista phenotype of C15²

(Campbell, 2005)

al^ice is a non-enhancer of empodium phenotype of C15²

(Campbell, 2005)

al^ice is a non-enhancer of pulvillus phenotype of C15²

(Campbell, 2005)

al^ice is a non-enhancer of tarsal segment 4 phenotype of C15²

(Campbell, 2005)

al^ice is a non-enhancer of pretarsus phenotype of C15²

(Campbell, 2005)

al^ice is a non-enhancer of unguis phenotype of C15²

(Campbell, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The leg and antennae phenotypes of C15²; al^ice double mutants are indistinguishable from either single mutant.

(Campbell, 2005)

The lethality of al^ice, Lim1^R12.4 double mutants acts during the embryonic stages, whereas lethality of either allele alone acts at the pharate adult stage.

(Pueyo et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

al^ice/Df(2L)al is rescued by al^B38

(Campbell et al., 1993)

al^vin/al^ice is rescued by al^B38

(Campbell et al., 1993)

al^ice is rescued by al^B38

(Campbell et al., 1993)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

59027

y¹ w^*; al^ice/CyO

Notes on Origin

Discoverer

Comments

Associated with an incompletely characterized chromosome rearrangement.

(Campbell et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

al^ice

(Tajiri et al., 2007, Wehn and Campbell, 2006)

Name Synonyms

alice

Secondary FlyBase IDs

References (10)

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