FlyBase Allele Report: Dmel\Sos[e2H]

General Information

Symbol

Dmel\Sos^e2H

Species

D. melanogaster

Name

FlyBase ID

FBal0030263

Feature type

allele

Associated gene

Dmel\Sos

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Simon et al., 1991)

Amino acid replacement: W579term.

(Simon et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:13,816,065..13,816,065 [+]

Nucleotide change:

G13816065A

Reported nucleotide change:

G?A

Amino acid change:

W579term | Sos-PA

Reported amino acid change:

W579term

Comment:

TGG to TGA

(Simon et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage 17

(Malartre et al., 2010)

lethal - all die before end of pupal stage | recessive

(Simon et al., 1991)

some die during pupal stage | recessive

(Simon et al., 1991)

Phenotype Manifest In

commissure | embryonic stage 17

(Malartre et al., 2010)

larval longitudinal connective | embryonic stage 17

(Malartre et al., 2010)

photoreceptor cell R7

(Simon et al., 1991)

Detailed Description

Statement

Reference

Sos^e2H homozygous mutant embryos exhibit axon crossing defects.

(Malartre et al., 2010)

Heterozygous loss of Sos has no effect on size of Nf1 mutant pupae.

(The et al., 1997)

Reduces the ability of a cell to develop as an R7 cell or as any other photoreceptor.

(Simon et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sos^e2H has abnormal neuroanatomy | embryonic stage 17 phenotype, enhanceable by Vav²

(Malartre et al., 2010)

Enhancer of

Statement

Reference

Sos^e2H is an enhancer of abnormal neuroanatomy | embryonic stage 17 phenotype of Vav²

(Malartre et al., 2010)

NOT Enhancer of

Statement

Reference

Sos^e2H is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Sos^e2H is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

Sos^e2H is a suppressor of abnormal locomotor rhythm phenotype of Nf1^P1

(Williams et al., 2001)

Sos^e2H is a suppressor of abnormal locomotor rhythm phenotype of Nf1^P2

(Williams et al., 2001)

NOT Suppressor of

Statement

Reference

Sos^e2H is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Sos^e2H is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Other

Statement

Reference

Df(3R)rn20, Sos^e2H has lethal | dominant phenotype

(Bergeret et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

Sos^e2H has larval longitudinal connective | embryonic stage 17 phenotype, enhanceable by Vav²

(Malartre et al., 2010)

Sos^e2H has commissure | embryonic stage 17 phenotype, enhanceable by Vav²

(Malartre et al., 2010)

Enhancer of

Statement

Reference

Sos^e2H is an enhancer of larval longitudinal connective | embryonic stage 17 phenotype of Vav²

(Malartre et al., 2010)

Sos^e2H is an enhancer of commissure | embryonic stage 17 phenotype of Vav²

(Malartre et al., 2010)

NOT Enhancer of

Statement

Reference

Sos^e2H is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Sos^e2H is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

Sos^e2H is a suppressor | partially of eye phenotype of Krn^UAS.cRa, Scer\GAL4^GMR.PF

(Reich and Shilo, 2002)

Sos^e2H is a suppressor | partially of ommatidium phenotype of Krn^UAS.cRa, Scer\GAL4^GMR.PF

(Reich and Shilo, 2002)

Sos^e2H is a suppressor of phenotype of rho^hs.sev

(Freeman, 1994)

NOT Suppressor of

Statement

Reference

Sos^e2H is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Sos^e2H is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous Sos^e2H enhances the axon tract phenotypes seen in vav² homozygous mutant embryos, with an increased number of midline crosses per embryo. No other CNS defects are observed.

(Malartre et al., 2010)

Weakly enhances the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

Enhances the sev^B4 phenotype: disrupts sev^B4 protein signalling.

(Simon et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sos^e2H is rescued by Sos^+t10

(Simon et al., 1991)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong allele.

(Simon et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

E(sev)2A^e2H

(Simon et al., 1991)

Sos^E2H

(Verheyen et al., 1996)

Sos^e2H

sos^e2H

(Malartre et al., 2010, Yang and Bashaw, 2006, Sullivan and Rubin, 2002, Bergeret et al., 2001, Freeman and Bienz, 2001)

sos^ezH

(Reich and Shilo, 2002)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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