FlyBase Allele Report: Dmel\N[Ax-M3]

General Information

Symbol

Dmel\N^Ax-M3

Species

D. melanogaster

Name

FlyBase ID

FBal0029942

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

Also Known As

Ax^M3

Key Links

Allele class

antimorphic allele - genetic evidence

gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(de Celis and Garcia-Bellido, 1994, Mari-Beffa et al., 1991)

gain of function allele

(Sotillos et al., 1997, Mari-Beffa et al., 1991)

Mutagen

ethyl methanesulfonate

(de Celis et al., 1991)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The average size of clones induced in N^Ax-M3/N^Ax-16 mutant wing discs are larger all over the wing than in wild-type controls. Clones of over 2000 cells can be seen in the mutant discs (compared to a maximum of 600 in controls). This suggests that proliferation rate in N^Ax-M3/N^Ax-16 mutant wings is higher than in controls.

(Baonza and Garcia-Bellido, 2000)

Larvae have enlarged wing imaginal discs. Escapers have larger wings than normal and lack most sensory organs.

(Sotillos et al., 1997)

Rare escapers show length of microchaetae, macrochaetae and longitudinal wing veins is reduced with respect to that of wild type. The Abruptex phenotype of heteroallelic combinations with viable Abruptex alleles is reduced at 29^oC as compared to 25^oC.

(de Celis and Garcia-Bellido, 1994)

Heterozygotes have larger than normal wings and incomplete vein differentiation, specially in veins IV and V. Mitotic clones can appear anywhere in the wing. Elimination of the vein occurs only when a clone occupying vein territories is present in the dorsal and ventral surfaces. Clones along the wing margin do not cause nicks but are associated with loss of sensory elements in the anterior wing margin and with the differentiation of ectopic wing vein bristles in distal regions of the wing close to the margin.

(de Celis and Garcia-Bellido, 1994)

Phenotypes have topographic pattern specificities.

(Mari-Beffa et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

N^Ax-M3 has visible phenotype, suppressible by kuz^1405Rev11

(Sotillos et al., 1997)

NOT Enhancer of

Statement

Reference

N[+]/N^Ax-M3 is a non-enhancer of visible | somatic clone phenotype of emc¹

(Baonza et al., 2000)

NOT Suppressor of

Statement

Reference

N[+]/N^Ax-M3 is a non-suppressor of visible | somatic clone phenotype of emc¹

(Baonza et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

N^Ax-M3 has wing phenotype, suppressible by kuz^1405Rev11

(Sotillos et al., 1997)

N^Ax-M3 has sense organ phenotype, suppressible by kuz^1405Rev11

(Sotillos et al., 1997)

N^Ax-M3 has wing disc phenotype, suppressible by kuz^1405Rev11

(Sotillos et al., 1997)

Enhancer of

Statement

Reference

N^Ax-M3 is an enhancer of phenotype of emc^D

(Mari-Beffa et al., 1991)

N^Ax-M3 is an enhancer of phenotype of H^unspecified

(Mari-Beffa et al., 1991)

NOT Enhancer of

Statement

Reference

N[+]/N^Ax-M3 is a non-enhancer of wing vein | somatic clone phenotype of emc¹

(Baonza et al., 2000)

Suppressor of

Statement

Reference

N^Ax-M3 is a suppressor of phenotype of emc^unspecified

(Mari-Beffa et al., 1991)

NOT Suppressor of

Statement

Reference

N^Ax-M3/N^Ax-M3 is a non-suppressor | somatic clone of phenotype of emc¹/Df(3L)emc-E12

(Baonza et al., 2000)

N^Ax-M3/N^Ax-M3 is a non-suppressor of wing | somatic clone phenotype of emc¹/Df(3L)emc-E12

(Baonza et al., 2000)

N[+]/N^Ax-M3 is a non-suppressor of wing vein | somatic clone phenotype of emc¹

(Baonza et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The failure of emc¹/Df(3L)emc-E12 cells to form normal size clones in the wing is not rescued if the flies are also homozygous for N^Ax-M3. The width of wing veins formed by clones of homozygous emc¹ cells is unaffected if the flies are also heterozygous for N^Ax-M3.

(Baonza et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

See de Celis et al. 1992, Roux's Arch Dev Biol 200:64-76 and Diaz-Benjumea and Garcia Bellido 1990, Roux's Arch Dev Biol 198:336--354 .

(de Celis et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ax^M3

(Baonza and Garcia-Bellido, 2000, Baonza et al., 2000, Sotillos et al., 1997, de Celis and Garcia-Bellido, 1994, de Celis and Garcia-Bellido, 1994, de Celis et al., 1993, de Celis et al., 1991, Mari-Beffa et al., 1991)

N^Ax-M3

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close