FB2024_03 , released June 25, 2024
Allele: Dmel\Abd-BFab7-2
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General Information
Symbol
Dmel\Abd-BFab7-2
Species
D. melanogaster
Name
FlyBase ID
FBal0028657
Feature type
allele
Associated gene
Dmel\Abd-B
Associated Insertion(s)
Carried in Construct
Also Known As
Fab-72, Fab72
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Galloni et al., 1993)
Mutagen
Delta2-3 transposase
(Galloni et al., 1993)
gene conversion
(Hogga and Karch, 1995)
Progenitor genotype
Abd-Bblt
(Hagstrom et al., 1996, Hogga and Karch, 1995, Galloni et al., 1993)
Abd-BFab7-2.tHa
(Hogga and Karch, 1995)
Cytology
Description

Deletion of DNA.

(Mihaly et al., 1997)

Imprecise excision of the P{bluetail} insertion deleting the major hypersensitive sites HS1 and HS2 but leaving HS3.

(Hagstrom et al., 1996)

Deletion of two of the three DNaseI hypersensitive sites within the Fab-7 element.

(Zhou et al., 1996)

Gene conversion event in which the P{bluetail}Abd-Bblt insertion has been excised and the gap has been repaired using a P{Abd-BFab7-2} insertion at 12E as the donor template. This results in a specific deletion of 789bp in the Fab-7 boundary region.

(Hogga and Karch, 1995)

789bp deletion with a lesion in the Fab7 domain.

(Karch et al., 1994)

The P insertion plus 0.7kb of proximal flanking DNA is deleted, including at least one and possibly all of two of the three nuclease hypersensitive regions.

(Galloni et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Abd-BFab7-2 mutant adult flies primarily show an A6 to A7 transformation, as evidenced by the reduction of the A6 tergite.

      (Iampietro et al., 2008)

      A6 assumes A7 identity in Abd-BFab7-2 males, so that in adults most of the sixth tergite and sternite are absent. Some cells of A6 are visible as a small tergite which adopts A5 identity.

      (Hogga and Karch, 2002)

      In Abd-BFab7-2 heterozygous males the 6th segment (A6) assumes A7 identity: most of the sixth sternite and tergite are absent.

      (Hogga et al., 2001)

      Heterozygous males have a reduced A6 segment.

      (Lupo et al., 2001)

      Incomplete transformation of PS11 to PS12.

      (Hagstrom et al., 1997)

      Homozygotes show incomplete transformation of abdominal segment A6 to A7.

      (Mihaly et al., 1997)

      Transforms parasegment 11 to parasegment 12 identity.

      (Hagstrom et al., 1996)

      Incomplete transformation of abdominal segment 6 to A7 identity.

      (Karch et al., 1994)

      A6 is incompletely transformed into A7 in homozygotes. In homozygotes, a rudimentary 6th tergite is present.

      (Galloni et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Abd-BFab7-2 has abdominal segment 6 phenotype, enhanceable by barr[+]/barrL305

      (Lupo et al., 2001)

      Abd-BFab7-2 has phenotype, enhanceable by Pc3

      (Mihaly et al., 1997)

      Abd-BFab7-2 has phenotype, enhanceable by ScmD1

      (Mihaly et al., 1997)

      Abd-BFab7-2 has phenotype, enhanceable by Df(2R)trix

      (Mihaly et al., 1997)

      Abd-BFab7-2 has phenotype, enhanceable by Pcl10

      (Mihaly et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When barrL305/+ is added to Abd-BFab7-2/+, nearly a complete reduction of abdominal segment A6 in 17%-31% of animals.

      (Lupo et al., 2001)

      The heterozygous gain of function phenotype is enhanced by Polycomb group mutations such as Pc3, Pcl10, ScmD1 and Df(2R)trix.

      (Mihaly et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Associated with: Fab-72.

      (Hogga and Karch, 1995)
      Comments
      Comments

      Deletion removes the prominent nuclear hypersensitive sites I and II.

      (Karch et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (13)