FB2024_03 , released June 25, 2024
Allele: Dmel\Dlw1
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General Information
Symbol
Dmel\Dlw1
Species
D. melanogaster
Name
FlyBase ID
FBal0020718
Feature type
allele
Associated gene
Dlw
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Tiong et al., 1995)
Mutagen
gamma ray
(Tiong et al., 1995)
Progenitor genotype
Caused by aberration
In(3R)Dlw1
Cytology
Description

Lesion several kb upstream of the Dr gene.

(Milan et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the dorsal surface of the wing differentiate ventral structures.

      (Milan et al., 2001)

      Transforms ventral wing into dorsal wing. In clones, homozygous Dlw1 cells show transformation from dorsal to ventral.

      (Tiong and Bender, 1995)

      Transformation of ventral to dorsal wing compartment in heterozygotes. Extra copies of Dlw+, provided by Dp(3;1)B152, neither suppress or enhance the wing transformation of heterozygotes but does rescue the lethality of homozygotes who survive to adulthood with no sign of the wing transformation. Homozygous somatic dorsal clones induced at any larval stage show dorsal to ventral wing transformation, the two dorsal rows at the anterior triple row region are replaced by a single row with ventral bristle morphology. Ventral clones differentiate only wild type ventral bristles. Transformation by clones in the posterior wing compartment are seen by a double row of elongated hairs in the alula. Clones have no effect elsewhere except in the dorsal notum which may differentiate extra macrochaetes. Pc21 Dlw+/Pc+ Dlw1 double heterozygotes have an enhanced ventral to dorsal wing transformation.

      (Tiong et al., 1995)

      Heterozygotes display homeotic transformation of ventral to dorsal wing.

      (Tiong and Bender, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Dlw[+]/Dlw1, Scer\GAL4ptc-559.1 is a suppressor | partially of visible phenotype of BxUAS.Tag:HA, Scer\GAL4ptc-559.1

      (Milan et al., 2001)
      Other
      Statement
      Reference

      Dlw1, DrΔ68 has lethal phenotype

      (Milan et al., 2001)

      Dlw[+]/Dlw1, DrΔ68 has lethal phenotype

      (Milan et al., 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of BxScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ptc-559.1 in a Dlw1/+ background restores campaniform sensilla and corrugation on the dorsal surface of wing vein 3, indicating that these cells have dorsal identity. The wing is overgrown in these flies and an ectopic posterior wing margin is induced in the dorsal surface along the anterior-posterior compartment boundary.

      (Milan et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Dlw1 interacts with trx and Pc mutants.

      (Tiong and Bender, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dlw1
      Name Synonyms
      Secondary FlyBase IDs
        References (4)