FB2024_03 , released June 25, 2024
Allele: Dmel\wgP
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General Information
Symbol
Dmel\wgP
Species
D. melanogaster
Name
FlyBase ID
FBal0018510
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Progenitor genotype
Caused by aberration
Cytology
Description

Inversion breakpoint maps to the 3' regulatory region.

Break maps to approximately 9-11kb 3' to the end of the wg transcript.

Insertion breakpoint is within region +16.4 to +17.1 on the wg map.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous animals exhibit an outstretched wing phenotype. Although defects are seen in the dorsal wing hinge, the ventral wing hinge exhibits defects. The ywllo club is consistently either absent or much smaller than seen in wild-type. Some ventral hinges show deformation of the proximal ventral radius and pleural wing process.

30% of wgP/wg17en40cP1 flies show development of wing-like structures on the prothoracic segment, ranging from rudimentary to well formed. 25% of wg1/wgP flies have wings on the prothoracic segment, and mesothoracic wings and metathoracic halteres develop variably. 25% of wgl-17/wgP and wgl-16/wgP flies have wings on the prothoracic segment, and the mesothoracic wings and metathoracic halteres are always absent. 10% of wgl-16/wgP flies show a varying degree of transformation of the metathoracic legs to halteres, ranging from graded removal of the distal segments (tibia and tarsus), through distortion of the femur and graded removal of leg bristles, to transformation of the coxa and trochanter into the first and second segments of the haltere.

Heterozygotes exhibit an increase in the number of sternopleural bristles, affecting macro- and microchaetae. wgP/wgSp-1 individuals are lethal. Adult escapers lack one or both anterior dorsocentral bristles and more rarely also the posterior postalar bristle and the presutural bristle. They also exhibit loss of distal antennal segments and in rare cases exhibit antennal duplication. Individuals in combination with wgSp-revP, wgl-16 and wgl-17 are pupal lethal, when in combination with wgspd-j2 individuals die before pupariation. Individuals are adult viable and exhibit the wing phenotype when in combination with wg1.

bunrI043 mutant phenotype is suppressed by loss of one copy of hh, restored to wild type.

Similar mutant leg phenotypes, e.g. duplications and bifurcations, are produced by dsh clones, dsh, wg double heterozygotes and wg mutants. There is allele specificity in these interactions. A small fraction of wgP/wgl-17 pharate adults have misoriented bristles on the notum, head and abdomen.

Adult homeotic transformation of wing to notum.

pupal lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

wgP is a suppressor of pigment cell phenotype of sgl05007, wa

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Baker.

Comments
Comments

Homozygous embryos show a pair rule phenotype, though this phenotype is probably due to an unidentified (not prd) pair rule mutation on the chromosome. Hemizygous embryos show normal number of wg expressing stripes.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (13)