FlyBase Allele Report: Dmel\Ubx[Cbx-Hm]

General Information

Symbol

Dmel\Ubx^Cbx-Hm

Species

D. melanogaster

Name

Haltere mimic

FlyBase ID

FBal0017567

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Also Known As

Hm, Cbx^Hm

Key Links

Allele class

neomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

neomorphic allele - genetic evidence

(Botas et al., 1988)

Mutagen

Progenitor genotype

Caused by aberration

T(2;3)Hm

Cytology

Description

Deletion in the abx region of Ubx.

(Simon et al., 1990)

Translocation breakpoint at position -3077, located very close to the Ubx promoter.

(Bienz et al., 1988)

Breakpoint in the upstream region of Ubx.

(Botas et al., 1988)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Lindsley and Zimm, 1992)

visible | dominant

(Gonzalez-Gaitan et al., 1990, Botas et al., 1988, Bender et al., 1985)

visible | dominant | homeotic

(Micol and Garcia-Bellido, 1988)

visible | homeotic

(Mohit et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ubx^Cbx-Hm flies show a complete wing-to-haltere transformation that does not affect the T2 notum.

(Mohit et al., 2006)

Wing resembles a large haltere, but stalk is more winglike. In combination with vg, wing is further reduced and haltere almost completely eliminated.

(Lindsley and Zimm, 1992)

The mesothorax phenotype is reduced in combination with RpII215^Ubl. The dominant wing phenotype is 100% penetrant, occurring in the posterior and anterior compartment. Ubx^Cbx-Hm/Ubx¹⁹⁵ transheterozygotes show transformation of A1a towards T3a, and sometimes of T3p towards T2p.

(Gonzalez-Gaitan et al., 1990)

Transformation of parasegment 5 structures to parasegment 4.

(Simon et al., 1990)

Phenotype is fully penetrant in heterozygotes, and shows constant specificity.

(Botas et al., 1988)

Mesothoracic phenotype does not vary in the presence of extra copies of the bithorax complex, or with homologous chromosomes with breaks proximal to the bithorax complex.

(Micol and Garcia-Bellido, 1988)

Hemizygotes display transformation of posterior haltere towards wing, loss of first abdominal tergite and appearance of one or two legs from the first abdominal segment. In late embryos and larvae ventral setal belt of the first abdominal segment is transformed toward that of the third thoracic segment. Ventral pits and Keilin organs appear on abdominal segments A1 to A7, inclusive.

(Bender et al., 1985)

The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is increased in flies also containing a copy of Ubx^Cbx-Hm.

(Capdevila and Garcia-Bellido, 1981)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Ubx^Cbx-Hm has visible | dominant | homeotic phenotype, non-enhanceable by z^a693

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-Hm has visible | dominant | homeotic phenotype, non-enhanceable by z^a692

(Micol and Garcia-Bellido, 1988)

NOT suppressed by

Statement

Reference

Ubx^Cbx-Hm has visible | dominant | homeotic phenotype, non-suppressible by z^a692

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-Hm has visible | dominant | homeotic phenotype, non-suppressible by z^a693

(Micol and Garcia-Bellido, 1988)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Ubx^Cbx-Hm has adult mesothoracic segment phenotype, non-enhanceable by z^a693

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-Hm has adult mesothoracic segment phenotype, non-enhanceable by z^a692

(Micol and Garcia-Bellido, 1988)

NOT suppressed by

Statement

Reference

Ubx^Cbx-Hm has adult mesothoracic segment phenotype, non-suppressible by z^a692

(Micol and Garcia-Bellido, 1988)

Ubx^Cbx-Hm has adult mesothoracic segment phenotype, non-suppressible by z^a693

(Micol and Garcia-Bellido, 1988)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

872

T(2;3)Hm, Ubx^Cbx-Hm/In(2L)Cy, In(2R)Cy, Duox^Cy

Notes on Origin

Discoverer

Slatis, 5th Feb. 1949.

(Lindsley and Zimm, 1992)

Comments

The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpII215^Ubl. This reduction of the Cbx phenotype follows the order: Ubx^Cbx-Hm > Ubx^Cbx-2RM = Ubx^Cbx-2 = Ubx^Cbx-M1 > Ubx^Cbx-1RM = Ubx^Cbx-1 = Ubx^Cbx-3 = Ubx^Cbx-Twt.

(Gonzalez-Gaitan et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Cbx^Hm

(Makhijani et al., 2007, Mohit et al., 2006, Bajpai et al., 2004, Shashidhara et al., 1999, Micol and Garcia-Bellido, 1988)

(Castelli-Gair et al., 1992, Gonzalez-Gaitan et al., 1990, Simon et al., 1990, Bienz et al., 1988, Botas et al., 1988, Lipshitz et al., 1987, Bender et al., 1983)

Ubx^Cbx-Hm

bxd^Hm

(Bender et al., 1985)

bxdHm

(Camprodon and Castelli-Gair, 1994)

Name Synonyms

Haltere mimic

Secondary FlyBase IDs

References (16)

Report Sections

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