FlyBase Allele Report: Dmel\tld[6]

General Information

Symbol

Dmel\tld⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0016877

Feature type

allele

Associated gene

Dmel\tld

Associated Insertion(s)

Carried in Construct

Also Known As

tld^7M, tld^7M89

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Childs and O'Connor, 1994, Finelli et al., 1994)

Mutagen

ethyl methanesulfonate

(Finelli et al., 1994, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Amino acid replacement: R235H. Nucleotide substitution: G704A. Mutation within the protease domain.

(Childs and O'Connor, 1994)

The mutation falls in the protease domain of the tld protein.

(Finelli et al., 1994)

Amino acid replacement: R235H.

(Finelli et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:24,750,790..24,750,790 [+]

Nucleotide change:

G24750790A

Reported nucleotide change:

G704A

Amino acid change:

R245H | tld-PA

Reported amino acid change:

R235H

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

(Childs and O'Connor, 1994)

point_mutation

3R:24,750,790..24,750,790 [+]

Nucleotide change:

G24750790A

Reported nucleotide change:

G?A

Amino acid change:

R245H | tld-PA

Reported amino acid change:

R235H

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

(Finelli et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Finelli et al., 1994)

some die during embryonic stage | recessive

(Finelli et al., 1994)

Phenotype Manifest In

embryonic epidermis

(Finelli et al., 1994)

Detailed Description

Statement

Reference

Pupal lethal when heterozygous with the MBT chromosome.

(Riede, 2001)

Antagonistic activity towards dpp.

(Childs and O'Connor, 1994)

Weak ventralization.

(Finelli et al., 1994)

Weak ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

(Arora and Nusslein-Volhard, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ser^RX106, tld⁶ has lethal | pupal stage phenotype

(Riede, 2001)

btx^P, tld⁶ has lethal | larval stage phenotype