FB2024_03 , released June 25, 2024
Allele: Dmel\Su(H)6
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General Information
Symbol
Dmel\Su(H)6
Species
D. melanogaster
Name
FlyBase ID
FBal0016307
Feature type
allele
Associated gene
Dmel\Su(H)
Associated Insertion(s)
Carried in Construct
Also Known As
Su(H)HG36, l(2)br7HG36
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Schweisguth and Posakony, 1992)
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Furukawa et al., 1992)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Gubb et al., 1984)
Description

Nucleotide substitution: G1727A. Amino acid replacement: K261E.

(Furukawa et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,041,623..15,041,623 [+]
Nucleotide change:

G15041623A

Amino acid change:

E305K | Su(H)-PA; E305K | Su(H)-PC

(Furukawa et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are lethal during pupal development.

      Heterozygous flies carrying out 10 training sessions to test memory of odours do not display a lower 24 hour memory in spaced training (rest periods between tasks) compared to control flies.

      (Song et al., 2009)

      Su(H)8/Su(H)6 late third instar larvae are almost totally devoid of crystal cells, but have plasmatocyte cell counts equal to Su(H)8 or Su(H)6 heterozygotes. These larvae also have increased numbers of prophenoloxidase expressing cells in the larval lymph glands.

      (Duvic et al., 2002)

      Heterozygotes with a null allele show occasional double-shaft macrochaetes.

      (Schweisguth and Posakony, 1994)

      Fail to show the neurogenic imaginal disc phenotype when heterozygous with Df(2L)TE35BC-24.

      (Schweisguth and Posakony, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Su(H)6 is a suppressor of phenotype of H1

      (Furukawa et al., 1992)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Harrington.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (10)