FB2024_03 , released June 25, 2024
Allele: Dmel\rSu(b)
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General Information
Symbol
Dmel\rSu(b)
Species
D. melanogaster
Name
FlyBase ID
FBal0014375
Feature type
allele
Associated gene
Dmel\r
Associated Insertion(s)
Carried in Construct
Also Known As
Su(b)
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: E?K.

    (Simmons et al., 1999)

    Nucleotide substitution: G?A.

    (Simmons et al., 1999)

    Mutation maps within the second ATP binding site of the carbamyl phosphate synthetase domain of r (the CPS.B2 subdomain).

    (Simmons et al., 1999)

    Mutation located in either the B or X complementation group of r, perhaps within the CPSase domain.

    (Piskur et al., 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:16,659,960..16,659,960 [+]
    Nucleotide change:

    G16659960A

    Reported nucleotide change:

    G?A

    Amino acid change:

    E1167K | r-PA; E1167K | r-PD; E1167K | r-PE

    Reported amino acid change:

    E?K

    Comment:

    Position of mutation on reference sequence inferred by FlyBase curator based on author statement (see Figure 2). Same nucleotide substitution as rSu(b)DK7

    (Simmons et al., 1999)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Normalises the b phenotype. Homozygotes are resistant to three toxic pyrimidine analogs (5-fluorouracil, 6-azathymine and 6-azauracil). Mutation is associated with de novo pyrimidine biosynthesis.

        (Piskur et al., 1993)

        Semidominant. No sensitivity to 0.2M beta-alanine.

        (Campbell and Sherald, 1987)

        A semidominant suppressor of b; homozygotes and hemizygotes in combination with b are slightly darker than wild type, whereas heterozygotes are intermediate between b and wild type in cuticle reflectance. Su(b) by itself has no visible phenotype. Although supplementation of the medium with 6-azathymine, an inhibitor of dihydrouracil dehydrogenase, results in a dark body color in wild-type flies, it does not darken the wild-type coloration of Su(b); b. The double-mutant combination, Su(b) r, does not suppress b (Bahn and Sondergaard, 1983), whereas su(r) Su(b); b flies have enhanced black cuticle. Unlike su(b); b, the combination Su(b); b is not sensitive to dietary β-alanine (Campbell and Sherald, 1987). rSu(b) are resistant to toxic pyrimidine analogs. CPSase activity from rSu(b) is not, unlike that from the wild-type, strongly inhibited by UTP.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        rSu(b) is a suppressor of phenotype of bunspecified

        (Sondergaard and Kolbak, 1987, Pedersen, 1982)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Embryos that are homozygous for fs(1)pyrSu(b) rSu(b) and bunspecified and originate from a female homozygous for these 3 mutations show reduced viability; most progeny die at early developmental stages.

        (Piskur et al., 1999)

        Semidominant suppressor of b. rSu(b) bunspecified flies retain wild-type body colour in the presence of 6-azathymine. rSu(b) is suppressed by su(r)unspecified in a bunspecified background; rSu(b) su(r)unspecified bunspecified flies have an enhanced black body colour and dull red eyes.

        (Pedersen, 1982)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        rSu(b) has been mapped to the transition region between the ATCase and CPSase domains of r, which also contains the largest intron in the r locus.

        (Sondergaard and Kolbak, 1987)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (6)
        Reported As
        Symbol Synonym
        Su(b)
        (Simmons et al., 1998, Campbell and Sherald, 1987, Bahn and Sondergaard, 1983, Pedersen, 1982)
        Su(b)1
        (Piskur et al., 1994)
        Su(b)80l
        (Sondergaard and Kolbak, 1987)
        rSu(b)1
        (Piskur et al., 1999)
        rSu(b)
        Name Synonyms
        Suppressor of black
        Secondary FlyBase IDs
          References (12)